Encontrados 2 documentos, a visualizar página 1 de 1
Antibody response against selected epitopes in the HIV-1 envelope gp41 ectodoma...
Marcelino, Rute; Gramacho, Filipa; Martin, Francisco; Brogueira, Pedro; Janeiro, Nuno; Afonso, Claudia; Badura, Robert; Valadas, Emília; Mansinho, KamalThe ectodomain of gp41 is the target of potent binding and neutralizing antibodies (NAbs) and is being explored in new strategies for antibody-based HIV vaccines. Previous studies have suggested that the W164A-3S (3S) and EC26-2A4 (EC26) peptides located in the gp41 ectodomain may be potential HIV vaccine candidates. We assessed 3S- and EC26-specific binding antibody responses and related neutralizing activity ...
Characterization of a large cluster of HIV-1 A1 infections detected in Portugal...
Araújo, Pedro M.M.; Carvalho, Alexandre; Pingarilho, Marta; Faria, Domitília; Pinho, Raquel; Ferreira, José; Proença, Paula; Nunes, SofiaHIV-1 subtypes associate with differences in transmission and disease progression. Thus, the existence of geographic hotspots of subtype diversity deepens the complexity of HIV-1/AIDS control. The already high subtype diversity in Portugal seems to be increasing due to infections with sub-subtype A1 virus. We performed phylogenetic analysis of 65 A1 sequences newly obtained from 14 Portuguese hospitals and 425 ...