15 documents found, page 1 of 2
Advancing Atrial Fibrillation Research
Ferreira, Mónica; V, Geraldes; Felix, Ana Clara; Oliveira, Mario; Laranjo, Sergio; Rocha, IsabelFunding Information: This paper was funded by Funda\u00E7\u00E3o para a Ci\u00EAncia e a Tecnologia, reference number UIDB/00306/2020. Publisher Copyright: © 2025 by the authors.; Atrial fibrillation (AF) is the most prevalent sustained cardiac arrhythmia, presenting a significant global healthcare challenge due to its rising incidence, association with increased morbidity and mortality, and economic burden. Th...
Haemodynamic Patterns in Reflex Syncope
Laranjo, Sergio; Fonseca, Helena; Felix, Ana Clara; Gourine, Alexandre V.; Pinto, Fátima F.; Oliveira, Mario; Rocha, IsabelFunding Information: This paper was funded by Funda\u00E7\u00E3o para a Ci\u00EAncia e a Tecnologia, reference number UIDB/00306/2020. Publisher Copyright: © 2025 by the authors.; Introduction: Vasovagal syncope is a prevalent condition marked by transient loss of consciousness due to abrupt decreases in systemic blood pressure and/or heart rate. Despite its clinical impact, the underlying haemodynamic mechanis...
AFTER-CA
Ferreira, Mónica; Silva Cunha, Pedro; Felix, Ana Clara; Fonseca, Helena; Oliveira, Mario; Laranjo, Sergio; Rocha, IsabelPublisher Copyright: © 2024 by the authors.; Background: Catheter ablation (CA) is a well-established treatment for atrial fibrillation (AF). However, its effects on autonomic function and underlying mechanisms remain poorly understood. This study investigated autonomic and haemodynamic changes following CA and explored their potential implications for patient outcomes. Methods: Seventy-eight patients with AF u...
Linking Sleep Disorders to Atrial Fibrillation
Ferreira, Monica; Oliveira, Mario; Laranjo, Sergio; Rocha, IsabelFunding Information: This paper was funded by Funda\u00E7\u00E3o para a Ci\u00EAncia e a Tecnologia, reference number UIDB/00306/2020. Publisher Copyright: © 2024 by the authors.; Sleep is a complex biobehavioural process essential for overall health, with various dimensions including duration, continuity, timing, and satisfaction. This study investigated the intricate relationships between common sleep disorde...
Mathematical kinetic modelling followed by in vitro and in vivo assays reveal t...
Faustino, Maria; Lourenço, Tiago; Strobbe, Simon; Cao, Da; Fonseca, André; Rocha, Isabel; Van Der Straeten, Dominique; Oliveira, M. MargaridaFunding Information: This work was supported by FCT (Fundação para a Ciência e a Tecnologia) (2022.02916.PTDC, https://doi.org/ https://doi.org/10.54499/2022.02916.PTDC ), the Plants for Life PhD fellowship of MF (PD/BD/148694/2019), the contract of TL (CEECIND/03641/2017), the Research Unit "GREEN-IT – Bioresources for Sustainability" (UIDB/04551/2020, https://doi.org/ https://doi.org/10.54499/UIDB/04551/2020 ...
OsTH1 is a key player in thiamin biosynthesis in rice
Faustino, Maria; Lourenço, Tiago; Strobbe, Simon; Cao, Da; Fonseca, André; Rocha, Isabel; Van Der Straeten, Dominique; Oliveira, M. MargaridaFunding Information: MMO gratefully acknowledges FCT (Funda\u00E7\u00E3o para a Ci\u00EAncia e a Tecnologia) financial support through the project Rice2B (2022.02916.PTDC, https://doi.org/10.54499/2022.02916.PTDC ) \u201CModelling vitamins B1 and B2 biosynthesis and biofortification in rice\u201D, the Plants for Life PhD fellowship of MF (PD/BD/148694/2019), the contract of TL (CEECIND/03641/2017), and the Rese...
From plastic waste to bioprocesses
Balola, Alexandra; Ferreira, Sofia; Rocha, IsabelFunding Information: Although P. denitrificans is the only organism where this pathway has been fully characterized, Schada von Borzyskowski and colleagues have implemented the BHA cycle into P. putida KT2440 with the goal of assessing whether the implementation of this cycle would permit better growth than the natural EG oxidative pathway (Schada von Borzyskowski et al., 2023). In their work, a P. putida strai...
Computer-aided design and implementation of efficient biosynthetic pathways to ...
Ferreira, Sofia; Balola, Alexandra; Sveshnikova, Anastasia; Hatzimanikatis, Vassily; Vilaça, Paulo; Maia, Paulo; Carreira, Rafael; Stoney, RuthFunding Information: The author(s) declare that financial support was received for the research, authorship, and/or publication of this article. This project has received funding from the European Union\u2019s Horizon 2020 research and innovation programme under grant agreement 814408 SHIKIFACTORY100\u2013Modular cell factories for the production of 100 compounds from the Shikimate pathway. This work was suppor...
Central Autonomic Network Regions and Hypertension
Geraldes, Vera; Laranjo, Sérgio; Nunes, Catarina; Rocha, IsabelIntroduction: Hypertension, a leading cause of death, was investigated in this study to understand the role of specific brain regions in regulating blood pressure. The lateral parabrachial nucleus (LPBN), Kolliker-fuse nucleus (KF), and periductal grey matter (PAG) were examined for their involvement in hypertension. Methods: Lentiviral vectors were used to alter the activity of these brain regions in hypertens...
Orthostatic Stress and Baroreflex Sensitivity
Ferreira, Mónica; Laranjo, Sergio; Cunha, Pedro; Geraldes, Vera; Oliveira, Mário; Rocha, IsabelPublisher Copyright: © 2023 by the authors.; The abnormal neural control of atria has been considered one of the mechanisms of paroxysmal atrial fibrillation (PAF) pathogenesis. The baroreceptor reflex has an important role in cardiovascular regulation and may serve as an index of autonomic function. This study aimed to analyze the baroreceptor reflex’s role in heart rate regulation during upright tilt (HUT) in...