11 documents found, page 1 of 2
Harvesting the power of green synthesis: gold nanoparticles tailored for prosta...
Oliveira, Marco; Sousa, André; Sá, Sara; Soares, Sílvia; Pereira, Ana Cláudia; Rocha, Ana Catarina; Pais, Patrick; Ferreira, Diogo; Almeida, CátiaBiosynthetic gold nanoparticles (bAuNPs) present a promising avenue for enhancing biocompatibility and offering an economically and environmentally responsible alternative to traditional production methods, achieved through a reduction in the use of hazardous chemicals. While the potential of bAuNPs as anticancer agents has been explored, there is a limited body of research focusing on the crucial physicochemic...
Potential anticancer activity from food-isolated fungi extracts
Ferreira, Diogo; Rocha, Ana Catarina; Baylina, Pilar; Sieiro, Carmen; Fernandes, RúbenFungal species have demonstrated great potential to produce a wide range of metabolites, including enzymes, antibiotics, and other bioactive compounds with therapeutic interest. Prostate cancer (PCa) is one of the most frequent cancers in men. This type of tumors have high levels of heterogeneity, leading to therapeutic failures and increasing resistance against chemotherapeutic drugs. Hence, is essential to re...
Creation of a fungal library and screening of antimicrobial and anticancer acti...
Ferreira, Diogo; Hermida, Lara Areal; Rocha, Ana Catarina; Baylina, Pilar; Sieiro, Carmen; Fernandes, Rúben; BAYLINA MACHADO, PILARAccording to the World Health Organization, cancer and infectious diseases are two of the most problematic diseases nowadays. Cancer kills 10 million people every year and the emergence of resistance to antitumoral drugs is an important medical challenge. At the same time, antimicrobial resistance (AMR) is also a serious threat to human and environmental health. Besides mortality, AMR burdens healthcare service...
Virulence-linked mutations in rubredoxin reductase and glutaredoxin: impact on ...
Sá, Sara; Silva, Carina; Dias, Maria Clara; Veiga, Marlene; Lopes, Sofia; Fernandes, Ruben; Rocha, Ana Catarina; Pais, Patrick J.; Oliveira, MarcoPseudomonas aeruginosa (PAO1) is an opportunistic pathogen, lethal in immunocompromised individuals. The clinical management of PAO1 infections still depends deeply on antibiotic therapy. However, this therapy has been alarmingly overpowered by growing bacterial resistance mechanisms over the years. One of these bacterial mechanisms is quorum sensing (QS). QS is involved in the production of biofilm, rhamnolipi...
Improving biomethane production by adding conductive nanomaterials
Rocha, Ana Catarina; Braga, Cátia Sofia Neves; Oliveira, Inês; Soares, O. Salomé G.; Pereira, M. Fernando R.; Pereira, LucianaThe search for renewable energy sources is one of the top priorities of humanity. Biomethane production through anaerobic digestion (AD) could help to reduce the dependence on fossil energy. The addition of conductive nanomaterials (CM) to AD systems results in the acceleration of methane production (MP) and in the improvement of the resilience of these systems. However, the mechanisms underlying this phenomeno...
Unravelling the Warburg effect: glycolytic inhibitors as promising agents in ca...
Cunha, Andrea; Silva, Patrícia; Rocha, Ana Catarina; Queirós, OdíliaThe study of metabolic changes in cancer cells and their influence on tumor progression is still a challenge in oncobiology. Cancer cells are characterized by their high rates of glycolysis, even in the presence of oxygen, a phenomenon described as the Warburg effect. The increased glycolytic flux induces extracellular space acidification and boosts the more aggressive characteristics of cancer cells. Since mon...
Cannabidiol and terpene formulation reducing SARS-CoV-2 infectivity tackling a ...
Santos, Susana; Barata, Pedro; Charmier, Adilia; Lehmann, Inês; Rodrigues, Suzilaine; Melosini, Matteo M.; Pais, Patrick J.; Sousa, André P.In late 2019, COVID-19 emerged in Wuhan, China. Currently, it is an ongoing global health threat stressing the need for therapeutic compounds. Linking the virus life cycle and its interaction with cell receptors and internal cellular machinery is key to developing therapies based on the control of infectivity and inflammation. In this framework, we evaluate the combination of cannabidiol (CBD), as an anti-infla...
Enhanced 3T3-L1 differentiation into adipocytes by pioglitazone pharmacological...
Teixeira, Catarina; Sousa, André P.; Santos, Inês; Rocha, Ana Catarina; Alencastre, Inês; Pereira, Ana Cláudia; Martins-Mendes, Daniela; Barata, PedroDespite the primary function of pioglitazone in antidiabetic treatment, this drug is a potent inducer of PPAR-γ, a crucial receptor that is involved in adipocyte differentiation. In this work, we propose an optimized methodology to enhance the differentiation of 3T3-L1 fibroblasts into adipocytes. This process is crucial for adipocyte secretome release, which is fundamental for understanding the molecular mecha...
Ensaios in vitro de avaliação do efeito antitumoral de inibidores glicolíticos
Cunha, Andrea; Rocha, Ana Catarina; Silva, Daniela; Barbosa, Flávia; Sarmento, Bruno; Queirós, OdíliaA quimioterapia é particularmente tóxica para as células tumorais; porém, não é específica, sendo responsável por importantes efeitos adversos associados ao tratamento. O "Efeito Warburg" é uma característica do cancro, que consiste numa alteração metabólica na produção de energia da fosforilação oxidativa para a glicólise, mesmo na presença de O2. A ativação contínua da glicólise conduz a um rápido aumento de ...
Sala de aula invertida: infográfico
Rocha, Ana CatarinaO ensino em sala de aula invertida é uma nova metodologia que propõe revolucionar a sala de aula tradicional. É unânime! No modelo sala de aula invertida existe um aumento de motivação e melhores resultados escolares.