16 documents found, page 1 of 2

Boosting textiles with plant extracts: an advanced sustainable antimicrobial in...

This study investigates the incorporation of natural plant extracts, particularly eucalyptus and hop, into knitted fabrics to develop antimicrobial textiles. The antibacterial activity of the functionalized fabrics was evaluated against two pathogenic bacteria (Staphylococcus aureus and Escherichia coli) and one common skin commensal (Staphylococcus epidermidis). Biocompatibility with human skin cells was asses...

Sustainable textiles with plant extracts for skin applications

The expanding market for antimicrobial textiles demands innovative products to support modern technological advancements across various industries. This growing need includes the food industry, where antimicrobial textiles are vital for preventing contamination through uniforms and surface coverings; healthcare institutions, which utilize these products to reduce infection spread; consumer goods such as clothin...

2-Aryladenine derivatives as a potent scaffold for adenosine receptor antagonis...

A set of 2-aryl-9-H or methyl-6-morpholinopurine derivatives were synthesized and assayed through radioligand binding tests at human A<inf>1</inf>, A<inf>2A</inf>, A<inf>2B</inf>, and A<inf>3</inf> adenosine receptor subtypes. Eleven purines showed potent antagonism at A<inf>1</inf>, A<inf>3</inf>, dual A<inf>1</inf>/A<inf>2A</inf>, A<inf>1</inf>/A<inf>2B</inf>, or A<inf>1</inf>/A<inf>3</inf> adenosine receptor...

Synthesis of novel 2,9-disubstituted-6-morpholino purine derivatives assisted b...

The phosphatidylinositol-3 kinase (PI3K) pathway is one of the most frequently activated pathogenic signalling cascades in a wide variety of cancers. In the last 15 years, there has been an increase in the search for selective inhibitors of the four class I isoforms of PI3K, as they demonstrate better specificity and reduced toxicity in comparison to existing inhibitors. A ligand-based and target-based rational...

A tandem reaction in the synthesis of new 4,8-disubstituted-pyrimido[5,4-d]pyri...

Pyrimido[5,4-d]pyrimidines are biologically important compounds with diverse activity depending on the substituent groups around the heterocycle. The 3,4-dihydropyrimido[5,4-d]pyrimidines are efficiently converted to the aromatic derivatives by Dimroth rearrangement promoted by reaction with piperidine, in a very slow process. Subsequently, the aromatic derivatives are converted to new 4,8-disubstituted-pyrimid...

2-Aryladenine derivatives as a potent scaffold for A1, A3 and dual A1/A3 adenos...

From a collection containing more than 1500 academic compounds, in silico screening identified a hit for the human A1 adenosine receptor containing a new purine scaffold. To study the structure activity relationships of this new chemical series for adenosine receptors, a library of 24 purines was synthesized and tested in radioligand binding assays at human A1, A2A, A2B and A3 adenosine receptor subtypes. Fourt...

Reactivity of 6-imidatopurines with benzylhydrazine

Mycobacterium tuberculosis is a bacterium responsible for thousands of deaths worldwide [1]. Its acquired resistance referred to multi-drug resistance (MDR) is due to the restrictive choice of antibiotics, the prolonged course of therapy, globalization and continuous patient noncompliance [2]. Hence, MDR tuberculosis has led researchers worldwide in the quest to find novel drugs to combat these threatening new ...

Synthesis of new 9-(4´-RO-phenyl)-6-cyanopurine derivatives

Cancer remains to be one of the leading causes of death worldwide of which the scientific community continuously struggles to combat on a daily basis [1]. In developed countries, colorectal cancer is one of the most frequent types of cancer where busy and stressful lifestyles contribute to diets rich in unhealthy fats which can be a preliminary cause of this cancer [2]. Unfortunately, there is not a concrete cu...

6-Carbohydrazonamidepurines: Convenient Precursors for 4,8-Disubstituted Pyrimi...

A series of 4-arylamino-8-(alkyl or aryl)hydrazidepyrimido[5,4-d]pyrimidines was obtained efficiently from 6-carbohydrazonamidepurines by reaction with piperidine. The 6-carbo-hydrazonamidepurines were generated selectively by the reaction of 6-imidatopurine with hydrazides under acidic conditions.

Synthesis of new pyrimido[5,4-d]pyrimidines derivatives as potential antituberc...