Heart failure (HF) is highlighted by its burdening symptom-limited exercise capacity and recurrent hospitalizations. Despite substantial advances regarding disease-modifying drugs in HF with reduced ejection fraction, additional therapeutic strategies to improve quality of life are invaluable. Currently, iron deficiency (ID) is overwhelmingly recognized in over 30% to 50% of patients with stable chronic HF, whi...
Background: Endothelial dysfunction underlies cardiovascular disease that frequently affects aged individuals. Characterized by local decrease in nitric oxide, it results from down-regulation of endothelial nitric oxide synthase (eNOS) expression/activity. Aiming to elucidate the molecular mechanisms involved in age-related endothelial dysfunction and to unveil potential therapeutic targets, we tested how diet ...
Descrevem-se nove casos de processos neoplásicos de células B, com baixa densidade de Ig da membrana. Em todos estes casos se observa uma alta percentagem de MRFC e a presença de antigénios da classe II do MHC. Dos nove doentes apresentados, oito têm um quadro clínico e laboratorial típico de LLC e um tem um quadro compatível com uma LLC na sua fase inicial. A identificação dos isotipos da Ig de membrana sugere...