4 documents found, page 1 of 1
In silico approaches for drug repurposing in oncology: protocol for a scoping r...
Cavalcante, Bruno Raphael Ribeiro; Freitas, Raíza Dias; Rocha, Leonardo de Oliveira Siquara da; Rocha, Gisele Vieira; Pachêco, Túlio Cosme de CarvalhoPrograma Nacional de Apoio à Atenção Oncológica (PRONON). Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). INOVA Fiocruz. Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP). Fundação Maria Emília. Instituto Gonçalo Moniz, Fundação Oswaldo Cruz.; Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Escola de Medicina. Departamento d...
Ru(II)-thymine complex causes DNA damage and apoptotic cell death in human colo...
Silva, Suellen Laila Rocha; Baliza, Ingrid R. S.; Dias, Rosane Borges; Sales, Caroline Brandi Schlaepfer; Rocha, Clarissa Araújo GurgelRu(II)-thymine complex [Ru(PPh3)2(Thy)(bipy)]PF6 (where PPh3 = triphenylphosphine, Thy = thyminate and bipy = 2,2′-bipyridine) is a potent cytotoxic agent with ability to bind to DNA, inducing caspase-mediated apoptosis in leukemia cells. In this study, we investigated the mechanism underlying the cell death induction by Ru(II)-thymine complex in human colon carcinoma HCT116 cells, as well as its effect in xeno...
Ruthenium(II) complexes with 6-methyl-2-thiouracil selectively reduce cell prol...
Bomfim, Larissa Mendes; Araujo, Fênix Alexandra de; Dias, Rosane Borges; Sales, Caroline Brandi Schlaepfer; Rocha, Clarissa Araújo GurgelRuthenium(II) complexes with 6-methyl-2-thiouracil cis-[Ru(6m2tu)2(PPh3)2] (1) and [Ru(6m2tu)2(dppb)] (2) (where PPh3 = triphenylphosphine; dppb = 1,4-bis(diphenylphosphino)butane; and 6m2tu = 6-methyl-2-thiouracil) are potent cytotoxic agents and able to bind DNA. The aim of this study was to evaluate in vitro cellular underlying mechanism and in vivo effectiveness of these ruthenium(II) complexes in human acu...
Anti-liver cancer activity in vitro and in vivo induced by 2-pyridyl 2,3-thiazo...
Silva, Thiago David dos Santos; Bomfim, Larissa Mendes; Rodrigues, Ana Carolina Borges da Cruz; Dias, Rosane Borges; Sales, Caroline Brandi SchlaepferSubmitted by Renorbio (renorbioba@ufba.br) on 2018-05-02T18:48:24Z No. of bitstreams: 1 ANTI-LIVER CANCER ACTIVITY IN VITRO AND IN VIVO INDUCED BY 2-PYRIDYL 2,3-THIAZOLE DERIVATIVES.pdf: 2793458 bytes, checksum: fcbb9a4336522af9d68dd7cdd4ded487 (MD5); Approved for entry into archive by Delba Rosa (delba@ufba.br) on 2018-05-04T14:23:31Z (GMT) No. of bitstreams: 1 ANTI-LIVER CANCER ACTIVITY IN VITRO AND IN VIVO I...