2 documents found, page 1 of 1
The neglected contribution of streptomycin to the tuberculosis drug resistance ...
Rocha, DMGC; Viveiros, M; Saraiva, M; Osório, NSThe airborne pathogen Mycobacterium tuberculosis is responsible for a present major public health problem worsened by the emergence of drug resistance. M. tuberculosis has acquired and developed streptomycin (STR) resistance mechanisms that have been maintained and transmitted in the population over the last decades. Indeed, STR resistant mutations are frequently identified across the main M. tuberculosis linea...
Heterogeneous Streptomycin Resistance Level Among Mycobacterium tuberculosis St...
Rocha, DMGC; Magalhães, C; Cá, B; Ramos, A; Carvalho, T; Comas, I; Guimarães, JT; Bastos, HN; Saraiva, M; Osório, NSWidespread and frequent resistance to the second-line tuberculosis (TB) medicine streptomycin, suggests ongoing transmission of low fitness cost streptomycin resistance mutations. To investigate this hypothesis, we studied a cohort of 681 individuals from a TB epidemic in Portugal. Whole-genome sequencing (WGS) analyses were combined with phenotypic growth studies in culture media and in mouse bone marrow deriv...