4 documents found, page 1 of 1
Tropane alkaloids from the stem bark of Erythroxylum bezerrae
Brito, Luana San de O.; Pinto, Francisco das Chagas L.; Moraes Filho, Manoel Odorico de; Rocha, Danilo D.; Mendoza, Maria Fernanda M.Six previously undescribed tropane alkaloids, designated as erythrobezerrines A-F, were isolated from the EtOH extract from the stem bark of Erythroxylum bezerrae Plowman. Their structures were elucidated based on the interpretation of the NMR and MS data and in some instances, confirmed by X-ray diffraction analysis. The cytotoxicity of the isolated compounds was evaluated against the cancer cell lines L929, P...
New flavone and other compounds from Tephrosia egregia: assessing the cytotoxic...
Teixeira, Maria V. S.; Lima, Jefferson Q.; Pimenta, Antônia T. A.; Silva, Francisca R. L. da; Oliveira, Maria da Conceição F. de; Pereira, Italo G.The organic extracts from stems, roots and leaves of Tephrosia egregia Sandwith, Fabaceae, provided anew flavone, 5-hydroxy-8-(1 ,2 -epoxy-3 -hydroxy-3 -methylbutyl)-7-methoxyflavone (1), in additionto eleven known compounds: pongaflavone (2), praecansone B (3), 12a-hydroxyrotenone (4), praecan-sone A, 2 ,6 -dimethoxy-4 ,5 -(2 ,2 -dimethyl)-pyranochalcone, pongachalcone, maackiain, -sistosteroland its glucoside...
Potent antileukemic action of naphthoquinoidal compounds : evidence for an intr...
Cavalcanti, Bruno C.; Cabral, Igor O.; Rodrigues, Felipe A. R.; Barros, Francisco W. A.; Rocha, Danilo D.; Magalhães, Hemerson I. F.; Moura, Dinara J.The current study describes that nor-β-lapachone and its arylamino derivatives, iodinated and methylated naphthoquinones and nor-β-lapachone-based 1,2,3-triazoles exhibited pronounced cytotoxic effects against four human leukemia cell lines (HL-60, K562, Molt-4 and Jurkat). Nor-β- lapachones arylamino substituted with potent activity were identified, revealing themselves as potential prototypes against tumor ce...
Genetic toxicology evaluation of essential oil of Alpinia zerumbet and its chem...
Cavalcanti, Bruno C.; Ferreira, José R. O.; Cabral, Igor O.; Magalhães, Hemerson I. F.; Oliveira, Cecília C. de; Rodrigues, Felipe A. R.Essential oil (EO) of Alpinia zerumbet leaves, at non-toxic concentrations (50–300 l g/mL), did not induce genotoxicity in human leukocytes. However, at the highest concentration (500 l g/mL) tested caused a reduction in cell proliferation and viability, and an increase in DNA damage. Moreover, in vivo experi- ments showed that EO (400 mg/kg) did not exert mutagenicity on peripheral blood cells and bone mar- ro...