5 documents found, page 1 of 1
Natural products as new antimitotic compounds for anticancer drug development
Paier, Carlos Roberto Koscky; Maranhão, Sarah Sant’Anna; Carneiro, Teiliane Rodrigues; Lima, Lídia Moreira; Rocha, Danilo DamascenoCell cycle control genes are frequently mutated in cancer cells, which usually display higher rates of proliferation than normal cells. Dysregulated mitosis leads to genomic instability, which contributes to tumor progression and aggressiveness. Many drugs that disrupt mitosis have been studied because they induce cell cycle arrest and tumor cell death. These antitumor compounds are referred to as antimitotics....
Crotalus durissus cascavella venom toxicity to mammalian cells
Araújo, Lucelina da Silva; Rocha, Danilo Damasceno; Viana, Daniel Araújo; Silveira, João Alison de Moraes; Vasconcelos-Filho, Francisco Sérgio LopesSnakes from the genus Crotalus gained significant space in the scientific field since the development of researches with their venom involving cytotoxic activity. Crotalus durissus cascavella is the only subspecies recorded of the Caatinga biome of Northeastern Brazil and it’s noticed a lack of studies on its venom properties. The present study evaluated the crude venom of C. d. cascavella for its cytotoxic act...
Chromomycin A2 induces autophagy in melanoma cells
Guimarães, Larissa Alves; Jimenez, Paula Christine; Sousa, Thiciana da Silva; Freitas, Hozana Patrícia S.; Rocha, Danilo Damasceno; Wilke, Diego VerasThe present study highlights the biological effects of chromomycin A2 toward metastatic melanoma cells in culture. Besides chromomycin A2, chromomycin A3 and demethylchromomycin A2 were also identified from the extract derived from Streptomyces sp., recovered from Paracuru Beach, located in the northeast region of Brazil. The cytotoxic activity of chromomycin A2 was evaluated across a panel of human tumor cell ...
Efeito antitumoral da vitafisalina F e seus derivados : mecanismo e alvo de ação
Rocha, Danilo DamascenoWhitasteroids are steroidal lactones, structurally based on the ergostane skeleton, commonly found in plants of the family Solanaceae. In order to evaluate the antitumor potential of this class of compounds, Withaferin A, isolated from the plant Withania somnifera, and Whithaphysalin F, isolated from the plant Acnistus arborescens, were analyzed in several experimental models in vitro. Several analogues of Whit...
Estudo das atividades citotóxica e antitumoral de vitafisilinas isoladas de Acn...
Rocha, Danilo DamascenoWithaphysalins are C28-steroidal lactones structurally based on the ergostane skeleton commonly found in Solanaceae species. In order to evaluate the anticancer properties of these compounds, five withaphysalins [O, F, M, N and (17S,20R,22R)-5β,6β: 18,20-diepoxy-4β,18-dihydroxy-1-oxowitha-24-enolide] isolated from Acnistus arborescens, a plant from the northeastern Brazilian flora, were analyzed in several biol...