2 documents found, page 1 of 1
Revealing a novel Otubain-Like Enzyme from Leishmania infantum with deubiquitin...
Azevedo, Clênia dos Santos; Guido, Bruna Cândido; Pereira, Jhonata L.; Nolasco, Diego O.; Corrêa, Rafael; Magalhães, Kelly Grace; Motta, Flávia NaderDeubiquitinating enzymes (DUBs) play an important role in regulating a variety of eukaryotic processes. In this context, exploring the role of deubiquitination in Leishmania infantum could be a promising alternative to search new therapeutic targets for leishmaniasis. Here we present the first characterization of a DUB from L. infantum, otubain (OtuLi), and its localization within parasite. The recombinant OtuL...
Antileishmanial and trypanocidal activity of brazilian Cerrado plants
Mesquita, Mariana Laundry de; Desrivot, Julie; Bories, Christian; Fournet, Alain; Paula, José Elias de; Grellier, Philippe; Espindola, Laila SalmenThe side effects and the emerging resistance to the available drugs against leishmaniasis and trypanosomiasis led to the urgent need for new therapeutic agents against these diseases. Thirty one extracts of thirteen medicinal plants from the Brazilian Cerrado were therefore evaluated in vitro for their antiprotozoal activity against promastigotes of Leishmania donovani, and amastigotes of Trypanosoma cruzi. Amo...