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NADES-in-Oil Emulsions Enriched with Essential Oils for Cosmetic Application

Freitas, David; Rocha, Diana; Santos, Joana; Noro, Jennifer Martins; Tavares, Tânia D.; Teixeira, Marta O.; Araújo, Daniela; Castro, Joana Isabel Reis

This research aims to explore the potential benefits of natural deep eutectic solvents (NADES) in formulating translucent NADES-in-oil emulsions (TEs) containing essential oils (EOs) for cosmetic applications. The TEs investigated in this study are based on previous formulations, consisting of 50 wt.% egg phosphatidylcholine (EPC), 20 wt.% ethanol, 20 wt.% olive oil (OlO), thyme oil (TO), or oregano oil (OrO), ...


Pioneering wound care solutions: triaxial wet-spun fibers with bioactive agents...

Miranda, Catarina Alexandra Fortuna Santos; Marinho, Elina Margarida Ribeiro; Rocha, Diana; Silva, C.; Silva, Maria Manuela; Schlapp-Hackl, Inge

Fiber-based constructs have been produced as an alternative to conventional dressings for the treatment of chronic wounds (CWs), showing good tenability, high surface area and regulable porosity. A commonly used technique for processing such dressings is wet-spinning, which involves precipitating a polymer solution into a coagulation bath containing a non-solvent of that polymer. This process produces fibers wi...


Lyocell/silver knitted fabrics for prospective diabetic foot ulcers treatment: ...

Tavares, Tânia Daniela Eugénio; Ribeiro, Artur; Bengoechea, Carlos; Rocha, Diana; Alcudia, Ana; Begines, Belén; Silva, C.; Antunes, Joana Isabel Costa

Diabetic foot ulcers (DFUs) are a serious complication of diabetes, often resulting in infections and further health deterioration. Thus, the development of an approach combining different therapies in just one formulation to treat DFUs remains very challenging. Silver-plated polyamide fibers offer antimicrobial properties, while lyocell provides biodegradability, biocompatibility and moisture management abilit...


Laccase-catalyzed polymerized natural bioactives for enhanced mushroom tyrosina...

Costa, Diana; Rocha, Diana; Santos, Joana; Noro, Jennifer Martins; Ribeiro, Artur; Silva, Carla

Skin hyperpigmentation disorders, such as melasma, are linked to excessive melanin production, primarily regulated by the enzyme tyrosinase (TYR). While current inhibitors like kojic acid (KA) are effective, they often cause adverse side effects, driving the search for safer andnatural alternatives. This study evaluated the TYR inhibitory potential of bioactive-rich extracts from acorn, cocoa, cork, and eucalyp...


Thymol-loaded polycaprolactone wet-spun fibers and their ability to suppress ba...

Teixeira, Marta Sofia Aguiar Carvalho Oliveira; Pérez, Leonardo M; Pinho, Sonia L C; Ferreres, Guillem; Rocha, Diana; Freitas, David S; Tzanov, Tzanko

Chronic wounds (CWs) are labeled as a significant clinical challenge due to their complex treatment, often hindered by bacterial colonization and persistent inflammation. In this study, the potential of wet-spun polycaprolactone (PCL) fibers embedded with thymol (PCL-thy), a natural antibacterial, anti-inflammatory and antioxidant compound, was investigated for the treatment of CWs. The incorporation of thymol ...


Optimizing extraction from cork and almond wastes: the role of water in deep eu...

Rocha, Diana; Freitas, David; Santos, Joana; Ribeiro, Artur; Magalhães, Pedro; Silva, C.

Four deep eutectic mixtures (DES) with varying water concentrations (10% to 50%) were synthesized using naturally derived and biodegradable components: choline chloride:urea (ChCl:U), choline chloride:levulinic acid (ChCl:Lev), betaine:levulinic acid (Bet:Lev), and glycerol:phosphoric acid (Gly:Ph). These ternary mixtures, designed as greener alternatives to conventional solvents, were tested as substitutes of ...


Eggshell Calcification Pattern: An Incidental Finding

Rocha, Diana; Cruz, Rute Brás; Machado, Jorge; Pereira, Marta

Date: 2024   |   Origin: SPMI Case Reports

Acute Inferior Myocardial Infarction: Beyond the ST-Segment Elevation

Rocha, Diana; Simões, Pedro; Gouveia, João; Ferreira, Cátia; Franco, Fátima

Acute coronary syndromes (ACS) are considered a continuum, enclosing both non-ST-elevation (NSTE)-ACS, including unstable angina and non-ST-elevation myocardial infarction (NSTEMI), and ST-elevation myocardial infarction (STEMI). The diagnosis of myocardial infarction (MI) is associated with troponin release. Classification of MI has fundamentally been based on the presence or absence of ST-segment elevation (S...

Date: 2024   |   Origin: SPMI Case Reports

Bowen's Disease in an HIV-Positive Patient: Doença de Bowen em Doente com Infeç...

Rocha, Diana; Borralho, João; Brochado, Ana; Vaz Alves, João


Developing translucent emulsions using sustainable NADES-based extracts

Freitas, David; Rocha, Diana; Santos, Joana; Noro, Jennifer Martins; Tavares, Tânia D.; Teixeira, Marta O.; Araújo, Daniela; Castro, Joana

In this work, we explored natural deep eutectic solvents (NADES) for developing translucent NADES-in-oil emulsions (TEs) for cosmetic applications. NADES, composed of lactic acid and glycerol (1:1 and 1:4 ratios), were selected for their natural origin, non-toxicity, and compatibility with living organisms. These green solvents facilitated the extraction of bioactive compounds from Lavandula angustifolia, Corym...


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