Paraquat, a potent herbicide, can be highly toxic to fish, causing morphological and biochemical alterations in several organs, including induction of oxidative stress that may result in cellular damage. Since peroxisomes are vital regulators of reactive oxygen species, it was hypothesized that a subacute exposure of brown trout – a sensitive bioindicator – to a waterborne environmentally relevant concentration...
Background: Subcellular location of purine catabolism enzymes is of great interest in comparative studies due to the significant variability among species [1]. This metabolic pathway reflects in large extent a phylogenetic evolution with the loss of several enzymes in certain species, resulting in differences in the end products that are excreted [2]. Particularly in fishes, some of those enzymes are described ...
Triple-negative breast cancer (TNBC) represents an aggressive subtype of breast cancer (BC) with a typically poorer prognosis than other subtypes of BC and limited therapeutic options. Therefore, new drugs would be particularly welcome to help treat TNBC. Preussin, isolated from the marine sponge-associated fungus, Aspergillus candidus, has shown the potential to reduce cell viability and proliferation as well ...
Fucoxanthin (Fx) is a carotenoid derived from marine organisms that exhibits anticancer activities. However, its role as a potential drug adjuvant in breast cancer (BC) treatment is still poorly explored. Firstly, this study investigated the cytotoxic effects of Fx alone and combined with doxorubicin (Dox) and cisplatin (Cis) on a panel of 2D-cultured BC cell lines (MCF7, SKBR3 and MDA-MB-231) and one non-tumor...
Durante quase um século, as estações férreas funcionaram como ponto de embarque e desembarque de passageiros. Por volta de 1990 ocorre a interrupção de seu uso original e as edificações tornaram-se obsoletas e, por consequência, criaram-se territórios abandonados. Neste trabalho, busca-se explorar os territórios no entorno das estações férreas abandonadas, analisando as relações dessas edificações com quem habi...
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