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Adenosine A2A receptors facilitate synaptic NMDA currents in CA1 pyramidal neurons
Mouro, Francisco; Rombo, Diogo M.; Dias, Raquel Baptista; Ribeiro, Joaquim A.; Sebastião, Ana MBackground and purpose: NMDA receptors play a key role in both synaptic plasticity and neurodegeneration. Adenosine is an endogenous neuromodulator and through membrane receptors of the A2A subtype can influence both synaptic plasticity and neuronal death. The present work was designed to evaluate the influence of adenosine A2A receptors upon NMDA receptor activity in CA1 hippocampal neurons. We discriminated b...
Enhanced LTP in aged rats: detrimental or compensatory?
Pinho, Júlia; Vale, Ruben; Batalha, Vânia; Costenla, Ana Rita; Dias, Raquel Baptista; Rombo, Diogo M.; Sebastião, Ana M; De Mendonça, AlexandreAge-dependent memory deterioration has been well documented and yet an increase in rat hippocampal LTP upon aging has been reported. This poses the question of whether the enhanced LTP is a cause or an attempt to compensate the memory deficits described in aged rats. Hippocampal slices from young, adult and aged Wistar rats were pre-incubated, with an NMDA receptor (NMDAR) antagonist, memantine (1 μM, 4 h), and...
Extracellular alpha-synuclein oligomers modulate synaptic transmission and impa...
Diógenes, Maria José; Dias, Raquel Baptista; Rombo, Diogo M.; Vicente Miranda, Hugo; Maiolino, Francesca; Guerreiro, Patrícia; Nasstrom, ThomasParkinson's disease (PD) is the most common representative of a group of disorders known as synucleinopathies, in which misfolding and aggregation of α-synuclein (a-syn) in various brain regions is the major pathological hallmark. Indeed, the motor symptoms in PD are caused by a heterogeneous degeneration of brain neurons not only in substantia nigra pars compacta but also in other extrastriatal areas of the br...