15 documents found, page 1 of 2
In vitro bioaccessibility and intestinal transport of retinoic acid in ethyl ce...
Gonçalves, A; Viegas, Olga; Faria, A; Ferreira, MPLVO; Rocha, F; Estevinho, NThe development of carrier-based delivery systems for oral administration of retinoic acid (RA), that provides its release and absorption at intestinal level, is of major relevance in the treatment of acute promyelocytic leukemia. The aim of this work was to evaluate RA bioaccessibility and intestinal transport on ethyl cellulose (EC)- and EC + polyethylene glycol (ECP)-based microparticles and to understand th...
Microencapsulation of Enriched Extracts of Two Satureja Species by Spray Drying...
Fathi, F; Ebrahimi, SN; Pereira, DM; Berta Nogueiro Estevinho; Rocha, FBackground: Phenolic compounds are one of the main groups of secondary metabolites responsible for multiple biological and pharmacological properties that play a vital role in improving human health quality. Encapsulation by spray dryer creates protection toward the phenolic compounds as an efficient way for increasing product performance. Methods: The phenolic compounds of Satureja khuzistanica Jamzad (SKH) an...
ENCAPSULATION OF EXTRACTS FROM MIDDLE EAST MEDICINAL PLANTS AND ITS ADVANTAGES ...
Fathi, F; Ebrahimi, SN; Rocha, F; Berta Nogueiro EstevinhoMedicinal plants have played an important role in the development of human health care and culture, serving as both medicine and food. Herbal drugs have been used for centuries for the treatment of several diseases and many of the new medicines are produced based on recent research on their traditional uses. Medicinal plants of the Middle East are regarded as a rich resource of different valuable bioactive comp...
CELLULOSE CHEMISTRY AND TECHNOLOGY ENCAPSULATION OF EXTRACTS FROM MIDDLE EAST M...
Fathi, F; Ebrahimi, SN; Rocha, F; Berta Nogueiro EstevinhoMedicinal plants have played an important role in the development of human health care and culture, serving as both medicine and food. Herbal drugs have been used for centuries for the treatment of several diseases and many of the new medicines are produced based on recent research on their traditional uses. Medicinal plants of the Middle East are regarded as a rich resource of different valuable bioactive comp...
Preliminary studies of microencapsulation and anticancer activity of polyphenol...
Fathi, F; Ebrahimi, SN; Pereira, DM; Berta Nogueiro Estevinho; Rocha, FThe purpose of this study was to prepare functional formulations using two different types of Punica granatum (pomegranate) peels extracts (the native and the enriched extract), as an important source of polyphenolic compounds such as punicalagin and ellagic acid. These two extracts were microencapsulated by a spray-drying technique. Polyphenol constituents of P. granatum play a significant role in the preventi...
Vitamin D-related polymorphisms and vitamin D levels as risk biomarkers of COVI...
Freitas, AT; Calhau, C; Antunes, G; Araújo, B; Bandeira, M; Barreira, S; Bazenga, F; Braz, S; Caldeira, D; Santos, SCR; Faria, A; Faria, D; Fraga, MVitamin D is a fundamental regulator of host defences by activating genes related to innate and adaptive immunity. Previous research shows a correlation between the levels of vitamin D in patients infected with SARS-CoV-2 and the degree of disease severity. This work investigates the impact of the genetic background related to vitamin D pathways on COVID-19 severity. For the first time, the Portuguese populatio...
Geochemical, Mineralogical and Morphological Characterisation of Road Dust and ...
Candeias, C; Vicente, E; Tomé, M; Rocha, F; Ávila, P; Alves, CRoad dust resuspension, especially the particulate matter fraction below 10 µm (PM10), is one of the main air quality management challenges in Europe. Road dust samples were collected from representative streets (suburban and urban) of the city of Viana do Castelo, Portugal. PM10 emission factors (mg veh-1 km-1) ranging from 49 (asphalt) to 330 (cobble stone) were estimated by means of the United Stated Environ...
Fine Particulate Matter and Gaseous Compounds in Kitchens and Outdoor Air of Di...
Alves, C; Vicente, A; Oliveira, AR; Candeias, C; Vicente, E; Nunes, T; Cerqueira, M; Evtyugina, M; Rocha, F; Almeida, SMPassive diffusion tubes for volatile organic compounds (VOCs) and carbonyls and low volume particulate matter (PM2.5) samplers were used simultaneously in kitchens and outdoor air of four dwellings. PM2.5 filters were analysed for their carbonaceous content (organic and elemental carbon, OC and EC) by a thermo-optical technique and for polycyclic aromatic hydrocarbon (PAHs) and plasticisers by GC-MS. The morpho...
Genomic imbalances defining novel intellectual disability associated loci
Lopes, F; Torres, F; Soares, G; Barbosa, M; Silva, J; Duque, F; Rocha, M; Sá, J; Oliveira, G; Sá, MJ; Temudo, T; Sousa, S; Marques, C; Lopes, SBackground: High resolution genome-wide copy number analysis, routinely used in clinical diagnosis for several years, retrieves new and extremely rare copy number variations (CNVs) that provide novel candidate genes contributing to disease etiology. The aim of this work was to identify novel genetic causes of neurodevelopmental disease, inferred from CNVs detected by array comparative hybridization (aCGH), in a...
Passive monitoring of particulate matter and gaseous pollutants in Fogo Island,...
Alves, CA; Candeias, C; Nunes, TV; Tome, MJC; Vicente, ED; Avila, PF; Rocha, FAn air quality monitoring campaign by passive sampling techniques was carried out, for the first time, between November 2016 and January 2017 on the Cape Verdean island of Fogo, whose volcanic mountain rises up to 2829 m. Levels of SO2 and acid gases (HF, HCl, HNO3, H2SO4 and H3PO4) were, in most cases, below the detection limits. Alkylpentanes, hexane, cycloalkanes and toluene were the dominant volatile organi...