10 documents found, page 1 of 1
Editorial: Inflammation and biomarkers in osteoarthritis
Mobasheri, Ali; Fonseca, João Eurico; Gualillo, Oreste; Henrotin, Yves; Largo, Raquel; Herrero-Beaumont, Gabriel; Rocha, Francisco Airton CastroOsteoarthritis (OA) is the most common form of arthritis affecting more than 500 million people globally. It accounts for more pain and functional disability than any other musculoskeletal disease and is an important source of high societal and economic costs. Although the pathophysiology of OA is poorly understood, the risk factors associated with disease development are well-established. They include age, obe...
Cell sources of inflammatory mediators present in bone marrow areas inside the ...
Rocha, Francisco Airton Castro; Girão, Virgínia Claudia Carneiro; Nunes, Rodolfo de Melo; Pinto, Ana Carolina Matias Dinelly; Vidal, BrunoPurpose: To demonstrate the production of inflammatory mediators by cells located in bone marrow spaces inside rodent menisci. Methods: Mice subjected to transection of the medial collateral and anterior cruciate ligaments and meniscotomy (osteoarthritis model) or to a sham procedure, as well as non-operated (naive) mice and rats, had knee joints excised. Tissues were stained with hematoxylin-eosin and tartrate...
Tumor necrosis factor prevents Candida albicans biofilm formation
Rocha, Francisco Airton Castro; Alves, Anelise Maria Costa Vasconcelos; Rocha, Marcos Fábio Gadelha; Cordeiro, Rossana de Aguiar CordeiroCandida species are commensals but some develop biofilms in prosthetic materials and host surfaces that may represent up to 30% of deaths related to infections, particularly in immunosuppressed patients. Tumor necrosis factor (TNF) exhibits a plethora of functions in host defense mechanisms whereas excessive release of TNF in inflammation promotes tissue damage. Cytokines released in an inflammatory milieu may ...
Latin-American challenges and opportunities in rheumatology
Rocha, Francisco Airton CastroThe importance of diseases to mankind is very similar worldwide. However, social and environmental issues, not to mention political and individual aspects, affect the prevalence and management of diseases and their outcomes. I present a brief and tentative comment to illustrate that the Latin-American rheumatology community, despite relevant gains in recent years, has some challenges to face in order to improve...
Did Father Cicero suffer from rheumatism?
Rocha, Francisco Airton CastroFather Cicero Romao Batista is probably the most famous Ceará character of all time. An important protagonist of the Cariri region, situated in the south of Ceara State, in the late nineteenth century and the first third of the twentieth century, Father Cicero had great political and religious activity, as well as other less well-known achievements, for instance, his ecological teachings that led him to be awar...
Parasitoses intestinais : efeito protetor na artrite reumatoide?
Oliveira, Sandra Maximiano de; Gomides, Ana Paula Monteiro; Mota, Lícia Maria Henrique da; Lima, Caliandra Maria Bezerra LunaRheumatoid arthritis (RA) is a systemic autoimmune inflammatory disease, with a progressive course, characterized by chronic synovitis that may evolve with deformities and functional disability, and whose early treatment minimizes joint damage. Its etiopathogenesis is not fully elucidated but comprises immunologic responses mediated by T helper cells (Th1). An apparent minor severity of RA in patients from regi...
Strontium ranelate analgesia in arthritis models is associated to decreased cyt...
Nunes, Rodolfo de Melo; Martins, Morgana Ramos; Silva Junior, Francisco Saraiva da; Leite, Ana Caroline Rocha de Melo; Girão, Virgínia Cláudia CarneiroObjective We investigated the anti-inflammatory activity of strontium ranelate (SR) in arthritis models. Materials and methods Rats received 1 mg zymosan (Zy) or saline intra-articularly. Other groups were subjected to anterior cruciate ligament transection in the right knee, as an osteoarthritis (OA) model, or a sham procedure. Joint pain was assessed using the articular incapacitation and paw-pressure tests. ...
Vitamin D levels in juvenile idiopathic arthritis from an equatorial region
Studart, Sâmia Araújo de Sousa; Leite, Ana Caroline Rocha de Melo; Marinho, Aryana Lushese Lima Feitosa; Pinto, Ana Carolina Matias DinellyWe aimed to describe the serum levels of 25-hydroxyvitamin D (25OHD) in juvenile idiopathic arthritis (JIA) patients living in a low-latitude (3°43′S) region. Fifty JIA patients, 31 (62 %) female, seen between May 2012 and April 2013 in the northeast of Brazil had clinical data and serum collected for determination of 25OHD and parathyroid hormone (PTH) using a chemiluminescent ELISA; 20 age- and sex-matched co...
Anti-inflammatory and immunomodulatory effect of an extract of coccidioides pos...
Pinto, Ana Carolina Matias Dinelly; Cordeiro, Rossana de Aguiar; Sidrim, José Julio Costa; Leite, Ana Karine Rocha de MeloTrying to surpass host defenses, fungal infections alter the immune response. Components from nonpathogenic fungi present therapeutic anti-inflammatory and immunomodulating activities. This study reveals that proteins present in a Coccidioides posadasii extract provide anti-inflammatory benefit in experimental arthritis. Zymosan was given intra-articularly to rats and mice, and groups were pretreated with C. po...
PCR-REA as an important tool for the identification of Cryptococcus neoformans ...
Cordeiro, Rossana Aguiar; Costa, Ana Karoline Freire; Brilhante, Raimunda Sâmia Nogueira; Lima, Rita Amanda Chaves deThe extraordinary ability of Cryptococcus species to cause disease has focused the attention of scientists on finding ways to improve their identification methods. In this study, PCR- REA, manual methods (morphological and biochemical characteristics), API 20C and VITEK 2 were used to test identify a total of 30 Cryptococcus spp. from human and veterinary sources. PCR-REA was performed using the capsular region...