341 documents found, page 1 of 35
The Relevance of Plant-Based Diets and Micronutrient Supplementation for Body C...
Pinheiro, C.; Silva, F.; Rocha, I.; Martins, C.; Giesteira, L.; Dias, B.; Lucas, A.; Alexandre, A.M.; Ferreira, C.; Viegas, B.; Bracchi, I.Objectives: This study aimed to compare the anthropometry and body composition of vegetarian and omnivorous adults living in Portugal, while exploring nutritional and health parameters underlying observed differences. Methods: 425 omnivorous (OMNI), lacto-ovo-vegetarian (LOV), or vegan (VEG) healthy adults were recruited. Anthropometry was measured, and bioelectrical impedance analysis was performed. Participan...
Metabolic reconstruction of the human pathogen Candida auris: using a cross-spe...
Viana, Romeu; Carreiro, Tiago; Couceiro, Diogo; Dias, Oscar; Rocha, I.; Teixeira, Miguel CachoCandida auris is an emerging human pathogen, associated with antifungal drug resistance and hospital candidiasis outbreaks. In this work, we present iRV973, the first reconstructed Genome-scale metabolic model (GSMM) for C. auris. The model was manually curated and experimentally validated, being able to accurately predict the specific growth rate of C. auris and the utilization of several sole carbon and nitro...
Ecological modelling approaches for predicting emergent properties in microbial...
Berg, Naomi Iris van den; Machado, Daniel; Santos, Sophia Torres; Rocha, I.; Chacón, Jeremy; Harcombe, William; Mitri, Sara; Patil, Kiran R.Recent studies have brought forward the critical role of emergent properties in shaping microbial communities and the ecosystems of which they are a part. Emergent properties---patterns or functions that cannot be deduced linearly from the properties of the constituent parts---underlie important ecological characteristics such as resilience, niche expansion and spatial self-organization. While it is clear that ...
The first multi-tissue diel cycle genome-scale metabolic model of a woody plant...
Cunha, Emanuel; Silva, Miguel; Chaves, Inês; Demirci, H.; Lagoa, Davide Rafael Santos; Lima, Diogo; Rocha, Miguel; Rocha, I.; Dias, OscarIn the last decade, genome-scale metabolic models have been increasingly used to study plant metabolic behavior at the tissue and multi-tissue level under different environmental conditions. Quercus suber, also known as the cork oak tree, is one of the most important forest communities of the Mediterranean/Iberian region. In this work, we present the genome-scale metabolic model of the Q. suber (iEC7871), the f...
Enhancing acetic acid and 5-hydroxymethyl furfural tolerance of C. saccharoperb...
Alves, Rafael; Zetty-Arenas, Ana M.; Demirci, H.; Dias, Oscar; Rocha, I.; Basso, Thiago O.; Freitas, SindeliaIn this study, adaptive laboratory evolution (ALE) was applied to isolate four strains of Clostridium saccharoperbutylacetonicum able to grow in the presence of hemicellulosic hydrolysate inhibitors unsupported by the parental strain. Among them, isolate RAC-25 presented the best fermentative performance, producing 22.1g/L of ABE and 16.7g/L of butanol. Genome sequencing revealed a deletion in the arabinose tra...
A tangible interface for augmented reality visualisation in 4d echocardíography...
Dias, J. M. S.; Aurélio, M.; Carvalho, H.; Rosário, L.; Carvalho, L. S.; Rocha, I.ln this work, we report a Tangible Augmented Reality system that can be applied to interactive visualization scenarios in the cardiology medical field, such as in the teaching of medical techniques or the recognition of organs. Moreover, it can be used for more detailed and natural interaction with virtual models of organs or other physiological structures of the human body. The system allows users to naturally...
Model-guided development of an evolutionarily stable yeast chassis
Pereira, Filipa; Lopes, Hélder; Maia, Paulo; Meyer, Britta; Nocon, Justyna; Jouhten, Paula; Konstantinidis, Dimitrios; Kafkia, Eleni; Rocha, MiguelAbstract First-principle metabolic modelling holds potential for designing microbial chassis that are resilient against phenotype reversal due to adaptive mutations. Yet, the theory of model-based chassis design has rarely been put to rigorous experimental test. Here, we report the development of Saccharomyces cerevisiae chassis strains for dicarboxylic acid production using genome-scale metabolic modelling. Th...
MEMOTE for standardized genome-scale metabolic model testing
Lieven, Christian; Beber, Moritz E.; Olivier, Brett G.; Bergmann, Frank T.; Ataman, Meric; Babaei, Parizad; Bartell, Jennifer A.; Blank, Lars M.Reconstructing metabolic reaction networks enables the development of testable hypotheses of an organisms metabolism under different conditions1. State-of-the-art genome-scale metabolic models (GEMs) can include thousands of metabolites and reactions that are assigned to subcellular locations. Geneproteinreaction (GPR) rules and annotations using database information can add meta-information to GEMs. GEMs with ...
Publisher Correction: MEMOTE for standardized genome-scale metabolic model testing
Lieven, Christian; Beber, Moritz E.; Olivier, Brett G.; Bergmann, Frank T.; Ataman, Meric; Babaei, Parizad; Bartell, Jennifer A.; Blank, Lars M.An amendment to this paper has been published and can be accessed via a link at the top of the paper.
A reconciled version of the cork oak tree genome-scale metabolic model
Silva, Miguel Ângelo Fernandes da; Lima, Diogo Batista; Rocha, Miguel; Rocha, I.; Dias, OscarQuercus suber, commonly known as cork oak tree, is an evergreen tree which produces a thick bark (also known as cork) with multiple (a)biotic stress resistance properties (1). Due to corks natural characteristics, such as the low weight, excellent insulation and low permeability, the cellular structure has a significant economic value as it has multiple applications. For instance, it can be used as a wine bottl...