5 documents found, page 1 of 1
Understanding lactoferrin multifunctionality by analyzing the full spectrum of ...
Ferreira, Sofia; Guedes, Joana P.; Rocha, Juliana F.; Sousa, Sérgio F.; Rodrigues, L. R.; Côrte-Real, Manuela; Soares, Pedro; Cátia S. PereiraLactoferrin (LF) is a multifunctional protein involved in critical biological processes such as immune response, antimicrobial activity, and iron regulation [1]. Its diverse roles include inhibiting inflammation, infections, and carcinogenesis [2], as well as modulating cellular processes by targeting proton-pumping ATPases such as V-ATPases in cancer cells [3], F- ATPases in bacteria [4], and P-ATPases in yeas...
Bridging the gap between lactoferrin and V-ATPase through a multi-stage computa...
Pereira, Cátia Sofia Santos; Rocha, Juliana F.; Fernandes, Henrique S.; Rodrigues, Lígia R.; Côrte-Real, Manuela; Sousa, Sérgio F.Lactoferrin (Lf), a bioactive milk protein, exhibits strong anticancer and antifungal activities [1,2]. The search for Lf targets and mechanisms of action is of utmost importance to enhance its effective applications. A common feature among Lf-treated cancer and fungal cells is the inhibition of a proton pump essential for pH homeostasis called V-ATPase. Lf-driven V-ATPase inhibition leads to cytosolic acidific...
The milk-derived lactoferrin inhibits V-ATPase activity by targeting its V1 domain
Pereira, Cátia Sofia Santos; Rocha, Juliana F.; Fernandes, Henrique S.; Rodrigues, L. R.; Côrte-Real, Manuela; Sousa, Sérgio F.Lactoferrin (Lf), a bioactive milk protein, exhibits strong anticancer and antifungal activities. The search for Lf targets and mechanisms of action is of utmost importance to enhance its effective applications. A common feature among Lf-treated cancer and fungal cells is the inhibition of a proton pump called V-ATPase. Lf-driven V-ATPase inhibition leads to cytosolic acidification, ultimately causing cell deat...
Deciphering the interaction of lactoferrin with V-ATPase towardsa deeper unders...
Cátia S. Pereira; Rocha, Juliana F.; Fernandes, Henrique S.; Rodrigues, L. R.; Côrte-Real, Manuela; Sousa, Sérgio F.Lactoferrin (Lf), a bioactive milk protein, exhibits strong anticancer and antifungal activities. The search for Lf targets and mechanisms of action is of utmost importance to enhance its effective applications. A common feature among Lf-treated cancer and fungal cells is the inhibition of a proton pump called V-ATPase. Lf-driven V-ATPase inhibition leads to cytosolic acidification, ultimately causing cell deat...
Total Stereoselective Michael Addition of N- and S- Nucleophiles to a D-Erythro...
Rocha, Juliana F.; Freitas, David S.; Noro, Jennifer Martins; Silva Teixeira, Carla S.; Sousa, Cristina E. A.; Alves, Maria José ChãoThe synthesis of a 1,S-lactone 2,4-O-alkylidene-D-erythrose derivative was found to be a highly stereoselective template in Michael addition trough the reaction of a D-erythrosyl 1,5-lactone derivative with nitrogen and sulfur nucleophiles. The sulfur adducts formed are 1 (D-erythrose derivative):1 (nucleophile), and the nitrogen adducts are 1:2. Both were then treated under HCl to give 2,6-dideoxy-4-functional...