2 documents found, page 1 of 1
Chemical inhibition of β-glucocerebrosidase does not affect phagocytosis and ea...
Ribeiro, H.; Rocha, M. I.; Castro, H.; Macedo, M. F.Gaucher disease is a lysosomal storage disease in which a genetic deficiency in β-glucocerebrosidase leads to the accumulation of glycosphingolipids in lysosomes. Macrophages are amongst the cells most severely affected in Gaucher disease patients. One phenotype associated with Gaucher macrophages is the impaired capacity to fight bacterial infections. Here, we investigate whether inhibition of β-glucocerebrosi...
Biochemical profile and in vitro neuroprotective properties of Carpobrotus edul...
Rocha, M. I.; J, Nogueira-Rodrigues; Pereira, C.; Pereira, H.; Silva, Manuela F. G. M.; da Rosa Neng, N.; Nogueira, J. M. F.; Varela, J.This work reports the nutritional profile and in vitro neuroprotective properties of leaves of Carpobrotus edulis L, a medicinal and edible succulent species native to the coast of South Africa. Biomass was evaluated for proximate composition and for contents in carotenoids, liposoluble pigments and minerals. Hexane, dichloromethane, ethyl acetate and methanol extracts were prepared by Soxhlet extraction from d...