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Microscopic and molecular screening of myxosporeans in teleost fishes caught fr...

Background: Globally, the demand for fishery resources has increased significantly to meet the nutritional needs of the population. With the continuous increase in aquaculture and the introduction of new species, knowledge of the life cycle of infectious agents is essential, as it is crucial for public health and industry [1]. Myxosporeans are microscopic multicellular parasites belonging to the phylum Cnidaria...

Dissecting the sensory defects of bbs mutants in Caenorhabditis elegans

Ciliopathies encompass a group of genetic disorders affecting multiple organs due to dysfunction in cilia: highly conserved organelles found in most human cells. Bardet-Biedl Syndrome (BBS) is a rare ciliopathy characterized by multisystem abnormalities. BBS arises from defects in assembly, composition, or localization of the BBSome, a conserved eight-subunit protein complex crucial in ciliary transport. Sensor...

Parasitological research of myxozoans in 2 species of benthic fish from Northea...

Background: Myxozoa Grassé, 1970 constitutes a diverse and widespread group of endoparasites that mainly use fish as intermediate hosts and are frequently associated with increased mortality [1]. The increase in the commercialization of sole species in Portugal promotes economic growth in fishing industry and there are presently efforts to produce it in aquaculture. However, despite its commercial relevance, th...

Pyrazoles as potential modulators of inflammation through the inhibition of COX...

The inflammatory process is a complex and tightly regulated cascade of events that involves the production of prostaglandins (PG) by the inducible isoform cyclooxygenase 2 (COX-2) and the production of reactive pro-oxidant species. When the production of these mediators becomes excessive, it can lead to chronic inflammation and associated diseases such as diabetes, rheumatoid arthritis, and cancer. Unfortunatel...

Chronic hepatitis C treatment in HIV co‐infection in Portugal: Results from a c...

Direct-acting antiviral drugs (DAAs) have recently changed the paradigm of hepatitis C therapy, significantly improving treatment response rates, patient life expectancy and quality of life. In Portugal, sofosbuvir (SOF) and SOF/ledipasvir (SOF/LDV) were fully reimbursed by the National Health System since early 2015 and generalized use of interferon-free DAA based regimens became current practice. During 2016,...

A influência da natureza das tarefas na perceção dos alunos quanto à sua aprend...

In the Mathematics teaching context, the term task has a very particular meaning. In this article we propose to investigate how the task’s nature offered in the classroom can influence the students’ perception about their learning. Given the acknowledged difficulties in implementing certain tasks, we will focus our interest especially in learning based on problem solving. Thus, we realized three observations of...

A study towards drug discovery for the management of type 2 diabetes: Mellitus ...

The inhibition of carbohydrate-hydrolyzing enzymes, α-amylase and α-glucosidase, is one of the major therapeutic strategies for the treatment of type 2 diabetes mellitus. Chalcones have been recognized for their multiple biological activities, including antidiabetic properties, through unclear mechanisms. In the present work, a panel of chalcones bearing hydroxy, methoxy, methyl, nitro, chloro, fluoro and bromo...

Prevalence of Hepatitis A Virus Antibody in Portuguese Travelers: A New Paradigm

Introduction: In Portugal, the prevalence of hepatitis A virus infection has decreased in the past decades, especially in young adults. The aim of this study was to detect the prevalence of antibody to hepatitis A virus in a population observed in our Travel Clinic.Material and Methods: Antibodies against hepatitis A, hepatitis B, hepatitis C and human immunodeficiency virus were tested using standard enzyme im...

FABRY DISEASE IN PORTUGAL – INSIGHTS FROM THE MALE PATIENTS

PORTUGUESE CASUISTIC OF MUCOPOLYSACCHARIDOSES WITH CARDIAC MANIFESTATIONS