65 documents found, page 1 of 7

Gadoteric acid and gadolinium exposure – what is the impact on kidney gene expr...

Background: The nephrotoxicity of gadolinium [Gd (III)] has been reported, raising concerns about the safety of gadolinium-based contrast agents (GBCA). Gd (III) exposure, in renal tubular cells (HK-2), causes apoptosis, and leads to upregulation of genes related to lipogenesis/lipolysis and to signaling pathways related to inflammation/hypoxia [1].Gadoteric acid (Gd-DOTA), a macrocyclic GBCA, appears to be one...

Gadolinium and gadoteric acid exposure induce long-term down-regulation in eryt...

Background: Gadolinium-based contrast agents (GBCA) differ in their potential to release gadolinium [Gd (III)], known to be toxic. Gadoteric acid (Gd-DOTA) is a macrocyclic GBCA, with a more stable structure. After GBCA exposure, Gd (III) retention in red blood cells (RBC) and kidney has been reported [1,2]. Nephrogenic systemic fibrosis, a severe condition found in renal disease patients exposed to GBCA, is as...

Short-term and long-term effects of gadolinium and gadoteric acid exposure on r...

Background: There are currently concerns about the safety of gadolinium-based contrast agents (GBCA), as they can release gadolinium [Gd (III)], known to be toxic. Free Gd (III) deposition at different organs, as kidney and liver, has been reported [1,2]. We found that Gd (III) promotes inflammation and fibrosis in proximal tubular cells [3]. GBCA with macrocyclic structure, as gadoteric acid (Gd-DOTA), are con...

Exploring the associations between early maladaptive schemas and impulsive and ...

The main purpose of this preliminary study was to investigate a potential relationship between early maladaptive schemas (EMSs) and impulsive and compulsive buying tendencies in a sample of young adults (college students). This research adds to the cognitive perspective of consumer behavior that the cognitive schemas putatively associated with early experiences may have a strong impact on impulsive and compulsi...

Proximate composition of four seaweeds commonly found on the portuguese shore

Four macroalgae species, three red algae (Palmaria palmata, Gracilaria gracilis and Porphyra umbilicalis) and one green algae (Ulva rigida) were analysed to calculate and compare their proximate composition. These algae were grown in aquaculture in the same geography, and were also harvested in the same season. Ulva rigida differentiates the most from the other with higher contents of carotenoids and lower cont...

Modelo de formação das praças em regime de contrato: novas abordagens rumo à qu...

O modelo de profissionalização do serviço militar exige uma procura contínua de estratégias que permitam contribuir para atrair, recrutar e reter os militares, bem como garantir as condições adequadas à sua reinserção profissional. Assumindo a formação um papel essencial e prioritário neste contexto, emerge a necessidade permanente de avaliar e rever os modelos de formação e de carreira nas Forças Armadas, ante...

What drives beliefs in COVID-19 conspiracy theories? The role of psychotic-like...

Rationale The COVID-19 pandemic is a worldwide threat to public health and the global economy. The climate of fear and uncertainty associated with the pandemic has fostered the emergence of a wide range of COVID-19 conspiracy theories that have the potential to shape public opinion and hinder the effective dissemination of valid information. Beliefs in conspiracy theories have been associated with maladaptive p...

Rubinstein-Taybi Syndrome: When Phenotype is the Key

Moebius Syndrome and Depressor Anguli Oris Muscle Hypoplasia

Neonatal asymmetric crying facies is often underrecognized and is usually caused by hypoplasia/agenesia of the depressor angular oris muscle of the lip. This condition leads to newborn facial asymmetry of the mouth and lips while crying or smiling, being other functions of the facial muscles, such as frowning, eye closure, and nasolabial fold depth, normal. It differs from complete facial palsy, which can occur...

Subpopulations of High-Density Lipoprotein: Friends or Foes in Cardiovascular D...

Dyslipidemia is a major traditional risk factor for cardiovascular disease (CVD) in chronic kidney disease (CKD) patients, although the altered lipid profile does not explain the number and severity of CVD events. High-density lipoprotein (HDL) is a heterogeneous (size, composition, and functionality) population of particles with different atherogenic or atheroprotective properties. HDL-cholesterol concentratio...