2 documents found, page 1 of 1
The Octahydroindene Carboxyl Substructure from Dihydrobetulinic Acid is Essenti...
Rocha,Camila A.; Sanches,Paulo R. S.; Marchetto,Reinaldo; Zottis,AdersonThe dihydrobetulinic acid is a known competitive inhibitor of topoisomerase IB from Leishmania donovani, a validated target for developing new antileishmanial drugs. However, its binding mode and interaction pocket have not been established yet. We combined docking and molecular dynamics simulations to identify the most probable binding pocket. Our best model strongly suggests a cavity involving the residues ar...
The effect of Ageratum fastigiatum extract on Rhodnius nasutus, vector of Chaga...
Avelar-Freitas,Bethânia A.; Dias,João V. L.; Tibães,Gabrielle G.; Rocha,Camila A.; Bahia-Oliveira,Gustavo H.; Grael,Cristiane F. F.; Pires,Herton H. R.Control of Chagas disease is based on insecticide spraying in domiciles in order to exterminate triatomine populations. However, since the vectors differ in susceptibility to currently used insecticides, the screening of the toxic potential of Brazilian flora may identify new molecules lethal to triatomines. This study evaluated the toxicity of ethanolic extract of Ageratum fastigiatum (Gardner) R.M. King &...