4 documents found, page 1 of 1
New flavone and other compounds from Tephrosia egregia: assessing the cytotoxic...
Teixeira,Maria V.S.; Lima,Jefferson Q.; Pimenta,Antônia T.A.; Silva,Francisca R.L. da; Oliveira,Maria da Conceição F. de; Pereira,Italo G.ABSTRACT The organic extracts from stems, roots and leaves of Tephrosia egregia Sandwith, Fabaceae, provided a new flavone, 5-hydroxy-8-(1",2"-epoxy-3"-hydroxy-3"-methylbutyl)-7-methoxyflavone (1), in addition to eleven known compounds: pongaflavone (2), praecansone B (3), 12a-hydroxyrotenone (4), praecansone A, 2',6'-dimethoxy-4',5'-(2",2"-dimethyl)-pyranochalcone, pongachalcone, maackiain, β-sistosterol and i...
Miscellaneous Diterpenes from the Aerial Parts of Plectranthus ornatus Codd
Ávila,Fábio N.; Pinto,Francisco C. L.; Sousa,Thiciana S.; Torres,Maria Conceição M.; Costa-Lotufo,Leticia V.; Rocha,Danilo D.; Vasconcelos,Mayron A. deFive new diterpenes derivatives named as ornatin A, B, C, D and E, in addition to six known related diterpenes were isolated from the aerial parts of cultivated specimens of Plectranthus ornatus. The structures were elucidated using a combination of 1D/2D nuclear magnetic resonance (NMR) spectroscopy, high-resolution electrospray ionization mass spectrometry (HRESIMS) and comparison with published NMR data of a...
Cytotoxic Alkaloids from Hippeastrum solandriflorum Lindl.
Carvalho,Kaline R.; Silva,Alison B.; Torres,Maria Conceição M.; Pinto,Francisco Chagas L.; Guimarães,Larissa A.; Rocha,Danilo D.; Silveira,Edilberto R.One new alkaloid, 2α-10bα-dihydroxy-9-O-demethylhomolycorine, in addition to seven others known alkaloids, and 5-(hydroxymethyl)furfural, piscidic acid and eucomic acid, were isolated from the bulbs of Hippeastrum solandriflorum. The structures of all compounds were determined using nuclear magnetic resonance (NMR) spectroscopic techniques: 1H NMR and 13C NMR, heteronuclear single quantum coherence (HSQC), hete...
Potent antileukemic action of naphthoquinoidal compounds: evidence for an intri...
Cavalcanti,Bruno C.; Cabral,Igor O.; Rodrigues,Felipe A. R.; Barros,Francisco W. A.; Rocha,Danilo D.; Magalhães,Hemerson I. F.; Moura,Dinara J.The current study describes that nor-β-lapachone and its arylamino derivatives, iodinated and methylated naphthoquinones and nor-β-lapachone-based 1,2,3-triazoles exhibited pronounced cytotoxic effects against four human leukemia cell lines (HL-60, K562, Molt-4 and Jurkat). Nor-β-lapachones arylamino substituted with potent activity were identified, revealing themselves as potential prototypes against tumor cel...