5 documents found, page 1 of 1
Frequency of Th1 and Th17 Cells and IL‑17A Levels in Peripheral Blood and Perit...
Grilo,João; Santos,Catarina Reis; Coutinho,Joana; Barreto,Inês; Chorão,Raquel; Filipe,Rui Alves; Monteiro,Andreia; Fonseca,Mafalda; Rocha,ErnestoAbstract Introduction: Chronic kidney disease is characterized by an immune imbalance. In peritoneal dialysis (PD), chronic exposure to high‑load glucose solutions may further aggravate such disturbances. Among these inflammatory mediators, T helper 1 (Th1) and Th17 cells as well as interleukin 17A (IL‑17A) seem to stand out. We aimed to quantify the frequency of Th1 and Th17 cell subsets and IL‑17A levels in b...
Tough Decision Making in Pembrolizumab-Associated Acute Interstitial Nephritis:...
Grilo,João; Coutinho,Joana; Góis,Mário; Santos,Catarina Reis; Filipe,Rui Alves; Rocha,ErnestoABSTRACT Pembrolizumab is an immune checkpoint inhibitor used as a cancer therapy. The incidence of immune related adverse events in patients receiving immune checkpoint inhibitors can be as high as 59%-85. Renal adverse effects are uncommon, but the incidence of kidney toxicity related to pembrolizumab is rising as the use of this agent becomes more frequent. We present an uncommon case of biopsy-proven acute ...
Wunderlich Syndrome in a Peritoneal Dialysis Patient with Warfarin Iatrogenic C...
Carneiro,Juliana; Grilo,João; Coutinho,Joana; Chorão,Raquel; Rocha,ErnestoABSTRACT Wunderlich syndrome is a rare condition characterized by atraumatic spontaneous renal hemorrhage that can have serious associated complications, especially in chronic kidney disease and end-stage kidney disease patients due to their complexity. Diagnosis requires a high index of suspicion, since its classical presentation with Lenk’s triad is only seen in less than a quarter of patients. Early detectio...
Hypothyroidism and chronic kidney disease: An undervalued two-way relationship
Coutinho,Joana; Santos,Catarina Reis; Rocha,ErnestoThere is long-standing evidence that thyroid disease and kidney disease have a two-way relationship, as they can aggravate and lead to each other. The exact nature of this association and its clinical implications have been a matter of debate, as co-sharing of risk factors and appropriate prospective studies that allow for causal relationships to be inferred are lacking. Hypothyroidism is currently regarded by ...
Partial intestinal obstruction: a rare complication of autosomal dominant polyc...
Goncalves,Joao; Filipe,Rui; Santos,Catarina; Montalban,Jose; Ramalheiro,Antonio; Rocha,ErnestoAutosomal dominant polycystic kidney disease is a common disease with an estimated prevalence of 1 in 400-1000 people. It is a multisystem genetic disorder characterised by multiple bilateral kidney cysts, often accompanied by cysts in the liver and other organs. It is the cause of 5-7% of end-stage renal disease on chronic haemodialysis and can lead to various renal and extrarenal complications. We report an u...