5 documents found, page 1 of 1
Pattern of hemolysis parameters and association with fetal hemoglobin in sickle...
Moreira,Juliane Almeida; Laurentino,Marília Rocha; Machado,Rosângela Pinheiro Gonçalves; Barbosa,Maritza Cavalcante; Gonçalves,Ronaldo PinheiroObjective: This study aimed to evaluate the influence of fetal hemoglobin (Hb F) on hemolysis biomarkers in sickle cell anemia patients. Methods: Fifty adult sickle cell anemia patients were included in the study. All patients were taking hydroxyurea for at least six months and were followed at the outpatient clinic of a hospital in Fortaleza, Ceará, Brazil. The control group consisted of 20 hemoglobin AA indivi...
Influence of ?S-globin haplotypes and hydroxyurea on tumor necrosis factor-alph...
Laurentino,Marília Rocha; Maia Filho,Pedro Aurio; Barbosa,Maritza Cavalcante; Bandeira,Izabel Cristina Justino; Rocha,Lilianne Brito da SilvaBackground: Sickle cell anemia is a chronic inflammatory disease characterized by an increased production of proinflammatory cytokines including tumor necrosis factor-alpha. Hydroxyurea, by decreasing the polymerization of hemoglobin, reduces inflammatory states. The effect of the genetic polymorphisms of sickle cell patients on tumor necrosis factor-alpha levels remains unknown. Objective: The aim of this stud...
Kidney dysfunction and beta S-haplotypes in patients with sickle cell disease
Rocha,Lilianne Brito da Silva; Silva Jn,Geraldo Bezerra da; Daher,Elizabeth de Francesco; Rocha,Hermano Alexandre Lima; Elias,Darcielle Bruna DiasObjective: To investigate the association between kidney dysfunction and haplotypes in sickle cell disease. Methods: A cohort of 84 sickle cell disease patients, treated in a public health service in Fortaleza, Brazil, was studied. Hemoglobin S haplotypes were obtained from 57 patients as they had recently received blood transfusions with 18 of them agreeing to undertake urinary concentrating ability and acidif...
Correlation of low levels of nitrite and high levels of fetal hemoglobin in pat...
Elias,Darcielle Bruna Dias; Rocha,Lilianne Brito da Silva; Cavalcante,Maritza Barbosa; Pedrosa,Alano Martins; Justino,Izabel Cristina BandeiraBACKGROUND: Sickle cell disease is a hemoglobinopathy characterized by hemolytic anemia, increased susceptibility to infections and recurrent vaso-occlusive crises that reduces the quality of life of sufferers. OBJECTIVE: To evaluate the correlation of the levels of lactate dehydrogenase, malonaldehyde and nitrite to fetal hemoglobin in patients with sickle cell disease not under treatment with hydroxyurea in o...
Distribuição das mutações da β-talassemia em Fortaleza, Ceará
Rocha,Lilianne Brito da Silva; Martins,Michelle Freitas; Gonçalves,Romélia PinheiroINTRODUÇÃO: As mutações IVS-I-1, IVS-I-6 e CD 39 foram estudadas em 14 pacientes portadores de β-talassemia, da população de Fortaleza, capital do Ceará. OBJETIVO: Fornecer informações sobre a caracterização molecular dos pacientes β-talassêmicos de Fortaleza, contribuindo para traçar o perfil das mutações desta hemoglobinopatia na região Nordeste e no Brasil. MÉTODOS: A β-talassemia foi diagnosticada pelo estu...