4 documents found, page 1 of 1
Allyl Dibenzoylmethane Derivative: Antimelanoma Activity and Study of Its Molec...
Baeta,Jefferson V. P. B.; Andrade,Ulisses M. S.; Oliveira,Rayane M.; Oliveira,Leandro; Santos,Anésia A.; Diaz-Muñoz,Gaspar; Rocha,Márcio S.In this study, we assessed the cytotoxic effect of 1,3-diphenyl-2-allyl-1,3-propanedione (DPAP) on B16F10 and Tm5 melanoma cells and investigated its interaction with DNA (deoxyribonucleic acid) using optical tweezers. The compound showed to be effective against B16F10 cells with selectivity index (SI) of 7.92 and interaction to the outer surface of the double helix, probably at the minor groove of DNA. This li...
Theoretical and Experimental Investigations on Inclusion Complex β-Cyclodextrin...
Silva,Ivan S.; Feitosa,Eduardo L.; Santos,Márcio E. P.; Silva,Raiane M.; Rocha,Márcio S.; Silva,Francisco I. da; Lima,Francisco C. A.In this paper, we have applied state-of-the-art technologies and new investigations were developed focusing on obtaining simple and inexpensive molecules for treating cardiovascular diseases, as they are considered the leading cause of death in the world. For the first time, the inclusion complex of sulcatone (SU) and β-cyclodextrin (β-CD) was achieved (using a spray drier) and characterized making use of spect...
Preparação e caracterização do complexo de inclusão do óleo essencial de Croton...
Aguiar,Ulisses N.; Lima,Sidney G. de; Rocha,Márcio S.; Freitas,Rivelilson Mendes de; Oliveira,Talita M.; Silva,Raiane M.; Moura,Lara C. B.Croton zehntneri, a plant native to northeastern Brazil, is widely used in folk medicine to treat gastrointestinal problems and has rich essential oil content. The essential oil of C. Zehntneri was analyzed by GC-MS, and its inclusion complex with β-cyclodextrin (β-CD) was characterized by both vibrational spectroscopy and differential scanning calorimetry (DSC). Estragol was the major component identified in t...
New tools to study biophysical properties of single molecules and single cells
Rocha,Márcio S.; Mesquita,Oscar N.We present a review on two new tools to study biophysical properties of single molecules and single cells. A laser incident through a high numerical aperture microscope objective can trap small dielectric particles near the focus. This arrangement is named optical tweezers. This technique has the advantage to permit manipulation of a single individual object. We use optical tweezers to measure the entropic elas...