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Circulating levels of neurotrophic factors are unchanged in patients with Parki...
Rocha,Natalia Pessoa; Ferreira,João Paulo Sampaio; Scalzo,Paula Luciana; Barbosa,Izabela Guimarães; Souza,Mariana Soares de; Christo,Paulo PereiraABSTRACT There is great evidence linking neurotrophic factor (NF) dysfunction with Parkinson's disease (PD) pathophysiology. This study was conducted to evaluate plasma levels of NFs and their possible associations with clinical symptoms in PD. For this purpose, 40 PD patients and 25 controls were subjected to a clinical evaluation and peripheral blood draw. Plasma levels of brain-derived neurotrophic factor (B...
Revisiting the neuropsychiatry of Huntington's disease
Teixeira,Antonio Lucio; Souza,Leonardo Cruz de; Rocha,Natalia Pessoa; Furr-Stimming,Erin; Lauterbach,Edward C.ABSTRACT Huntington's disease (HD) is an autosomal dominant neurodegenerative disease classified under the choreas. Besides motor symptoms, HD is marked by cognitive and behavioral symptoms, impacting patients' functional capacity. The progression of cognitive impairment and neuropsychiatric symptoms occur in parallel with neurodegeneration. The nature of these symptoms is very dynamic, and the major clinical c...