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Tetraciclinas e glicilciclinas: uma visão geral
Pereira-Maia,Elene Cristina; Silva,Priscila Pereira; Almeida,Wagner Batista de; Santos,Hélio Ferreira dos; Marcial,Bruna Luana; Ruggiero,ReinaldoTetracyclines exhibits activity to a broad range of Gram-negative and Gram-positive bacteria and this fact allied to the low toxicity, low cost, and the advantage of administration by oral route led to their indiscriminate use, which caused the appearance of bacterial resistance to these agents, wich has restricted its clinical utility, though new applications have emerged. On the other hand, the glycylcyclines...
Estudo de modelagem molecular de complexos ferriprotoporfirina-IX e quinolinoca...
Silva,Thais Horta Álvares da; Oliveira,Marcelo Tavares de; Santos,Hélio Ferreira dos; Oliveira,Alaíde Braga de; De Almeida,Wagner BatistaQuinine and quinidine are well-known 4-quinolinecarbinolamines that exhibit antimalarial activity, but, in contrast, their epimers 9-epiquinine and 9-epiquinidine are almost inactive. Literature data are conflicting in describing the 4-quinolinecarbinolamine interaction mode with the molecular target, the ferriprotoporphyrin IX [Fe(III)PPIX]. In the present paper, a pharmacophore is proposed based on the bindin...