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Allergic inflammation triggers dyslipidemia via IgG signalling

Fernández-Gallego, Nieves; Castillo-González, Raquel; Moreno-Serna, Lucía; García-Cívico, Antonio J.; Sánchez-Martínez, Elisa; López-Sanz, Celia

Background: Allergic diseases begin early in life and are often chronic, thus creating an inflammatory environment that may precede or exacerbate other pathologies. In this regard, allergy has been associated to metabolic disorders and with a higher risk of cardiovascular disease, but the underlying mechanisms remain incompletely understood. Methods: We used a murine model of allergy and atherosclerosis, differ...


Allergic inflammation triggers dyslipidemia via IgG signalling

Fernández-Gallego, Nieves; Castillo-González, Raquel; Moreno-Serna, Lucía; García-Cívico, Antonio J.; Sánchez-Martínez, Elisa; López-Sanz, Celia

Allergic diseases begin early in life and are often chronic, thus creating an inflammatory environment that may lead to metabolic disorders, although the underlying mechanisms remain incompletely understood. Here, we show that allergic inflammation induces diet-independent dyslipidemia in a mouse model of allergy and atherosclerosis. Using untargeted lipidomics in mouse plasma, we found that allergic inflammati...


Microbial production of terpenes

Pimentel, Lígia; Carsanba, Erdem; Teixeira, Francisca; Vidigal, Susana; Pintado, Manuela; Oliveira, Carla; Rodríguez-Alcalá, Luis M.

Sustainability is one of the main challenges facing humankind in the twenty-first century due to the continuous increase in the demand for energy and resources that characterizes our current industrial activity, driven in part by exponential population growth. This problem can be tackled from different strategies and among them the search for biomolecules, either recovered through processes based on the circula...


Lipidomic studies involving steatosis induction using palmitic and linoleic fat...

Teixeira, Francisca S.; Pimentel, Lígia L; Vidigal, Susana S. M. P.; Azevedo-Silva, João; Pintado, Manuela E.; Rodríguez-Alcalá, Luis M.


Stability of a lyophilized milk enriched with microbial CLA/CLNA

Fontes, Ana L.; Pimentel, Lígia L.; Rodríguez-Alcalá, Luis M.; Gomes, Ana M.


Antioxidant activity evaluation of fermentation distillation residues

Soares, Ana M. S.; Teixeira, Francisca S.; Pimentel, Lígia L.; Vidigal, Susana S. M. P.; Costa, Paula T.; Pintado, Manuela E.; Rodríguez-Alcalá, Luis M.

Nature offers an unlimited variety of molecules with incredible biological activities, such as antioxidants among others, that are valuable for the maintenance of a good health by reducing the damage caused by oxidation [1,2]. This purpose allied to the richness of some wastes and by-products make distillation residues from industrial fermentation (FDRs) potential sources to obtain bioactive compounds. Accordin...


Impact of vegetable oils on lacticaseibacillus rhamnosus and bifidobacterium an...

Machado, Manuela; Sousa, Sérgio; Rodríguez-Alcalá, Luis M.; Gomes, Ana Maria; Pintado, Manuela



In situ milk enrichment with microbial CLA/CLNA using vegetable oils as substra...

Fontes, Ana L.; Pimentel, Lígia L.; Domingues, M. Rosário; Rodríguez-Alcalá, Luis M.; Gomes, Ana M.


Stability of a fermented milk enriched with microbial CLA/CLNA

Fontes, Ana L.; Pimentel, Lígia L.; Rodríguez-Alcalá, Luis M.; Gomes, Ana M.

There is an increasing interest towards the development of innovative value-added food products with a potential to prevent or counteract disease conditions, many times impelled by unbalanced diets, such as cardiovascular diseases and cancer. Several promising food-derived lipids with potential bioactive properties have been identified over the last decade, and these include conjugated linoleic (CLA) and conjug...


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