5 documents found, page 1 of 1
Glucosylated cholesterol accumulates in atherosclerotic lesions and impacts mac...
Marques, André R.A.; Ferreira, Inês; Ribeiro, Quélia; Ferraz, Maria J.; Lopes, Elizeth; Pinto, Daniela; J. Hall, Michael; JS, Ramalho; Artola, MartaAtherosclerosis can be described as a local acquired lysosomal storage disorder (LSD), resulting from the build-up of undegraded material in lysosomes. Atherosclerotic foam cells accumulate cholesterol (Chol) and glycosphingolipids (GSLs) within lysosomes. This constitutes the ideal milieu for the formation of a side product of lysosomal storage: glucosylated cholesterol (GlcChol), previously found in several L...
Cholesteryl hemiazelate identified in CVD patients causes in vitro and in vivo ...
Domingues, Neuza; Gaifem, Joana; Matthiesen, Rune; Saraiva, Diana P.; Bento, Luís; Marques, André R.A.; Soares, Maria I.L.; Sampaio, JulioFunding Information: supported by FCT through projects UIDB/00313/2020 and UIDP/00313/2020. Funding Information: R. S. group has been funded by national funds, through the FCT—project numbers UIDB/50026/2020 and UIDP/ 50026/2020 and 2020.00185. CEECIND to the FCT. Funding Information: N. D. was a holder of a PhD fellowship from the FCT (Ref. N◦: SFRH/BD/51877/2012). Funding Information: The authors acknowledge ...
Shotgun mass spectrometry-based lipid profiling identifies and distinguishes be...
Matthiesen, Rune; Lauber, Chris; Sampaio, Julio L.; Domingues, Neuza; Alves, Liliana; Gerl, Mathias J.; Almeida, Manuel S.; Rodrigues, GustavoFunding Information: This work was supported by PTDC/MED-PAT/29395/2017 financially supported by Fundação para a Ciência e a Tecnologia (FCT), through national funds and co-funded by FEDER under the PT2020 Partnership. ND was a holder of PhD fellowship from the FCT (Ref. No.: SFRH/BD/51877/2012), attributed by the Inter-University Doctoral Programme in Ageing and Chronic Disease (PhDOC). LA was a holder of a FC...
Sobrevida aos dez anos de pacientes submetidos a angioplastia coronária com ste...
Vale, Nelson; Madeira, Sérgio; Almeida, Manuel; Raposo, Luís; Freitas, Pedro; Castro, Mariana; Rodrigues, Gustavo; Oliveira, Afonso; Brito, JoãoIntroduction: Compared to bare-metal stents (BMS), drug-eluting stents reduce stent restenosis and improve subsequent revascularization rates. The impact on patients’ survival has been the subject of debate. Objective: To assess the long-term (10-year) survival of patients undergoing percutaneous coronary intervention (PCI) with first-generation sirolimus-eluting stents (SES) in comparison with BMS. Methods: In...
Cholesterol is Inefficiently Converted to Cholesteryl Esters in the Blood of Ca...
Gerl, Mathias J.; Vaz, Winchil L.C.; Domingues, Neuza; Klose, Christian; Surma, Michal A.; Sampaio, Júlio L.; Almeida, Manuel S.; Rodrigues, GustavoWe thank the nursing staff at the Hospital Santa Cruz, in particular Edite Tomas Mateus and Manuel Belo Costa for their enthusiastic involvement in this project and help in blood collection. This work was supported by iNOVA4Health - UID/Multi/04462/2013, a program financially supported by FCT (Foundation for Science and Technology of the Portuguese Ministry of Science and Higher Education) through national fund...