11 documents found, page 1 of 2

Evaluation of Amlodipine and Imipramine Efficacy to Treat Galleria mellonella I...

Funding Information: This work was supported by Funda\u00E7\u00E3o para a Ci\u00EAncia e a Tecnologia (FCT, Portugal) through funds to GHTM\u2014UID/04413/2020, LA-REAL\u2014LA/P/0117/2020, to the Project DREBI, Ref. 2022.07931.PTDC (DOI: 10.54499/2022.07931.PTDC), to the grants of M.A. (UI/BD/154472/2022) and J.N. (2022.07931.PTDC), and to the contracts of J.M. (DOI: 10.54499/CEECIND/00450/2017/CP1415/CT0001),...

Galleria mellonella research hub

Fundação para a Ciência e a Tecnologia through funds to DREBI Project Ref. 2022.07931. PTDC (doi: 10.54499/2022.07931.PTDC); GHTM (UID/04413/2020); LA-REAL (LA/P/0117/2020); UI/BD/154472/2022 (MA); 2022.07931.PTDC (JN) and CEECINST/00042/2021/CP1773/CT0009 (SSC); Galleria mellonella represents a sustainable invertebrate infection model that is gaining interest for pathogenicity and infection, host-pathogen inte...

Galleria mellonella

Financiamento: Fundação para a Ciência e a Tecnologia (FCT), Portugal, através de fundos para o Projeto DREBI Ref. 2022.07931.PTDC; GHTM (UID/04413/2020); LA-REAL (LA/P/0117/2020); Bolsa de doutoramento UI/BD/154472/2022 (MA); bolsa de BI 2022.07931.PTDC (JN) e CEECINST/00042/2021/CP1773/CT0009 (SSC); Galleria mellonella é um modelo larval de infeção que tem ganho destaque na comunidade científica para a avalia...

Drug repurposing for identification of new efflux inhibitors and/or antibiofilm...

Background Staphylococcus aureus (SA) and Staphylococcus epidermidis (SE) are frequent pathogens causing nosocomial infections. Efflux-mediated resistance and biofilm formation may contribute to the emergence of resistance in these species and resilience of such infections to chemotherapeutics. In this work, we applied an in silico drug repurposing strategy to identify drugs that can target efflux and/or biofil...

Drug repurposing for identification of new efflux inhibitors and/or antibiofilm...

Implementation of a Galleria mellonella infection model at GHTM/IHMT-NOVA

Drug Repurposing for COVID-19

Funding Information: This work was supported by Funda??o para a Ci?ncia e a Tecnologia (FCT) ?Apoio Especial RESEARCH4COVID-19 project no 434?. Funding Information: Funding: This work was supported by Fundação para a Ciência e a Tecnologia (FCT) “Apoio Especial RESEARCH4COVID-19 project no 434”. Publisher Copyright: © 2022, MDPI. All rights reserved.; In December 2019, the novel severe acute respiratory syndrom...

Efflux pump inhibitors as a promising adjunct therapy against drug resistant tu...

Introduction: In 2018, an estimated 377,000 people developed multidrug-resistant tuberculosis (MDR-TB), urging for new effective treatments. In the last years, it has been accepted that efflux pumps play an important role in the evolution of drug resistance. Strategies are required to mitigate the consequences of the activity of efflux pumps. Areas covered: Based upon the literature available in PubMed, up to F...

Contribution of Efflux to the Emergence of Isoniazid and Multidrug Resistance i...

pH Modulation of efflux pump activity of multi-drug resistant Escherichia coli ...

BACKGROUND: Resistance Nodulation Division (RND) efflux pumps of Escherichia coli extrude antibiotics and toxic substances before they reach their intended targets. Whereas these pumps obtain their energy directly from the proton motive force (PMF), ATP-Binding Cassette (ABC) transporters, which can also extrude antibiotics, obtain energy from the hydrolysis of ATP. Because E. coli must pass through two pH dist...