12 documents found, page 1 of 2
Glial-restricted precursors stimulate endogenous cytogenesis and effectively re...
Martins-Macedo, Joana; Araújo, Bruna; Anjo, Sandra I.; Silveira-Rosa, Tiago; Patrício, Patrícia; Alves, Nuno Dinis; Silva, Joana M.; Teixeira, Fábio G.Adult cytogenesis, the continuous generation of newly-born neurons (neurogenesis) and glial cells (gliogenesis) throughout life, is highly impaired in several neuropsychiatric disorders, such as Major Depressive Disorder (MDD), impacting negatively on cognitive and emotional domains. Despite playing a critical role in brain homeostasis, the importance of gliogenesis has been overlooked, both in healthy and dise...
StressMatic: a novel automated system to induce depressive- and anxiety-like ph...
Martins-Macedo, Joana; Mateus-Pinheiro, António; Alves, Cátia; Veloso, Fernando José Silva; Gomes, Eduardo D.; Ribeiro, Inês; Correia, Joana S.Major depressive disorder (MDD) is a multidimensional psychiatric disorder that is estimated to affect around 350 million people worldwide. Generating valid and effective animal models of depression is critical and has been challenging for neuroscience researchers. For preclinical studies, models based on stress exposure, such as unpredictable chronic mild stress (uCMS), are amongst the most reliable and used, ...
Evaluation of the genetic risk for COVID-19 outcomes in COPD and differences am...
Marçalo, Rui; Neto, Sonya; Pinheiro, Miguel; Rodrigues, Ana J.; Sousa, Nuno; Santos, Manuel A. S.; Simão, Paula; Valente, Carla; Andrade, LíliaPopulations seem to respond differently to the global pandemic of severe acute respiratory syndrome coronavirus 2. Recent studies show individual variability in both susceptibility and clinical response to COVID-19 infection. People with chronic obstructive pulmonary disease (COPD) constitute one of COVID-19 risk groups, being already associated with a poor prognosis upon infection. This study aims contributing...
Evidence for lack of direct causality between pain and affective disturbances i...
Guimarães, Marco Rafael Machado; Soares, Ana R.; Cunha, Ana M.; Esteves, Madalena; Borges, Sónia; Magalhães, Ricardo José SilvaChronic pain is frequently accompanied by the manifestation of emotional disturbances and cognitive deficits. While a causality relation between pain and emotional/cognitive disturbances is generally assumed, several observations suggest a temporal dissociation and independent mechanisms. We therefore studied Sprague-Dawley rats that presented a natural resistance to pain manifestation in a neuropathy model (sp...
Sorting nexin 3 mutation impairs development and neuronal function in Caenorhab...
Vieira, Neide; Bessa, Carlos; Rodrigues, Ana J.; Marques, Paulo; Chan, Fung-Yi; Carvalho, Ana Xavier de; Neves, Margarida Correia; Sousa, NunoThe sorting nexins family of proteins (SNXs) plays pleiotropic functions in protein trafficking and intracellular signaling and has been associated with several disorders, namely Alzheimer's disease and Down's syndrome. Despite the growing association of SNXs with neurodegeneration, not much is known about their function in the nervous system. The aim of this work was to use the nematode Caenorhabditis elegans ...
Impact of the Secretome of Human Mesenchymal Stem Cells on Brain Structure and ...
Teixeira, Fábio G.; Carvalho, Miguel M.; Panchalingam, Krishna M.; Rodrigues, Ana J.; Mendes-Pinheiro, Bárbara; Anjo, Sandra I.; Manadas, BrunoResearch in the last decade strongly suggests that mesenchymal stem cell (MSC)-mediated therapeutic benefits are mainly due to their secretome, which has been proposed as a possible therapeutic tool for the treatment of Parkinson's disease (PD). Indeed, it has been shown that the MSC secretome increases neurogenesis and cell survival, and has numerous neuroprotective actions under different conditions. Addition...
Day and night surgery: is there any influence in the patient postoperative peri...
Fernandes, S.; Carvalho, Ana Raquel Franky Gomes; Rodrigues, Ana J.; Costa, Patrício Soares; Sanz, Moreno; Goulart, André; Rios, Hugo; Leão, PedroBackground Medical activity performed outside regular work hours may increase risk for patients and professionals. There is few data with respect to urgent colorectal surgery. The aim of this work was to evaluate the impact of daytime versus nighttime surgery on postoperative period of patients with acute colorectal disease. Methods A retrospective study was conducted in a sample of patients with acute colorect...
Stress induced risk-aversion is reverted by D2/D3 agonist in the rat
Morgado, Pedro; Marques, Fernanda; Ribeiro, Beatriz; Leite-Almeida, Hugo; Pêgo, José M.; Rodrigues, Ana J.; Dalla, Christina; Kokras, Nikos; Sousa, NunoStress exposure triggers cognitive and behavioral impairments that influence decision-making processes. Decisions under a context of uncertainty require complex reward-prediction processes that are known to be mediated by the mesocorticolimbic dopamine (DA) system in brain areas sensitive to the deleterious effects of chronic stress, in particular the orbitofrontal cortex (OFC). Using a decision-making task, we...
Aptidão física na escola
Rodrigues, Ana J.Durante a última década, temse assistido a um crescente interesse no estudo da aptidão física pela comunidade científica, tal é indissociável da sua íntima relação com diversos indicadores de saúde. Da diversidade de métodos de avaliação da aptidão física, a bateria de testes motores Fitnessgram, pelo seu caracter prático, por permitir uma análise normativa e por orientações programáticas do PNEF, tem predomin...
Desempenho motor. Um estudo normativo e criterial em crianças da Região Autónom...
Afonso, Gil H.; Freitas, Duarte L.; Carmo, José M.; Lefevre, Johan A.; Almeida, Maria J.; Lopes, Vitor P.; Neves, Ana C.; Rodrigues, Ana J.O objectivo central do presente estudo foi construir valores de referência para os ‘skills’ locomotores e de controlo dos objectos em crianças da Região Autónoma da Madeira, Portugal. A amostra envolveu 853 sujeitos, 426 rapazes e 427 raparigas, que participaram na pesquisa ‘Crescer com Saúde na Região Autónoma da Madeira’. Os ‘skills’ motores fundamentais foram avaliados através do ‘Test of Gross Motor Develop...