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Liposomal formulations for efficient delivery of a novel, highly potent pyrimid...
Teixeira, Sofia; Ferreira, Débora Carina Gonçalves Abreu; Rodrigues, Ana Rita Oliveira; Rodrigues, L. R.; Castanheira, Elisabete M. S.Background/Objectives: Cancer is one of the deadliest diseases worldwide. Despite the existing treatments, the adverse side effects and the increasing drug resistance to the current therapies lead to a reduced quality of life for patients and poor prognosis. The pyrimido[5,4-d]pyrimidine compound (PP) was identified as a promising new anticancer drug due to its potent activity against colorectal and triple-nega...
Evaluation of the photothermal performance of the Prussian blue/hydroxyapatite ...
Costa, Achilley Nahid Barros; Serra, Josilene Lima; da Luz Rodrigues, Israel; Mendonça, Leonardo Tadeu Boaes; Pereira, GoretiIn this study, Prussian Blue (PB) and hydroxyapatite (HAp) composites were developed and synthesized in situ within an alginate gel, resulting in materials with excellent photothermal conversion efficiency. Structural information and morphology of the composites were obtained by using X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), UV–vis absorption spectroscopy, and Scanning Electron M...
New cation sensors based on eugenol-derived azo dyes
Coelho, José R. A.; Pacheco, Ana Rita Faria; Domingues, Diogo C.; Rodrigues, Ana Rita Oliveira; Temitope, Akani A.; Coutinho, Paulo J. G.Eugenol-based azo dyes illustrate how bio-sourced compounds like eugenol can be transformed through synthetic processes into functional and colorful compounds. The main purpose of the present work was to develop new responsive colorimetric sensors for metal cations based on eugenol-derived azo compounds. The incorporation of the azo group into the eugenol framework allows for strong electronic interactions with...
Elastic liposomes containing calcium/magnesium ferrite nanoparticles coupled wi...
Pacheco, Ana Rita Faria; Barros, Ana Margarida; Amorim, Carlos O.; Amaral, Vítor S.; Coutinho, Paulo J. G.; Rodrigues, Ana Rita OliveiraThis work reports on the design, development, and characterization of novel magneto-plasmonic elastic liposomes (MPELs) of DPPC:SP80 (85:15) containing Mg0.75Ca0.25Fe2O4 nanoparticles coupled with gold nanorods, for topical application of photothermal therapy (PTT). Both magnetic and plasmonic components were characterized regarding their structural, morphological, magnetic and photothermal properties. The magn...
Introdução aos softwares e aplicações de apoio ao trabalho experimental
Rodrigues, Ana Rita OliveiraNeste documento, apresenta-se um resumo introdutório e uma breve descrição de metodologias relativos a softwares e aplicações (Perusall, Tracker e Phyphox) aplicadas à realização de atividades experimentais.
NIR triggered elastic liposome containing magneto-plasmonic nanoparticles for t...
Pacheco, Ana Rita Faria; Barros, Ana Margarida Macedo Veloso; Castanheira, Elisabete M. S.; Rodrigues, Ana Rita OliveiraElastic liposomes (ELs) are excellent nanocarrier for topical applications due to their ultra-deformable properties. The integration of magnetic and plasmonic nanoparticles into these Els, forming magneto-plasmonic elastic liposomes, (MPELs) is a promising approach with potential to treat topical disease conditions. The combination of both magnetic and plasmonic components in a single system maximize the cell d...
Zinc/magnesium ferrite nanoparticles functionalized with silver for optimized p...
Fernandes, Ricardo Jorge Cunha; Cardoso, Beatriz D.; Rodrigues, Ana Rita Oliveira; Pires, Ana; Pereira, André M.; Araújo, João P.; Pereira, LucianaWater pollution is a major environmental challenge. Due to the inefficiency of conventional wastewater treatment plants in degrading many organic complex compounds, these recalcitrant pollutants end up in rivers, lakes, oceans and other bodies of water, affecting the environment and human health. Semiconductor photocatalysis is considered an efficient complement to conventional methods, and the use of various n...
Highly fluorescent 2‐Aminopurine derivatives: synthesis, photo‐physical charact...
Gonçalves, Jorge M.; Gonçalves, João N. D.; Pêra, Ana S.; Senhorães, Nádia R.; Rodrigues, Ana Rita Oliveira; Oliveira, Rui Pedro Soares deNew fluorescent nucleobase analogues (FBAs) are emerg-ing as extraordinarily useful tools for DNA labelling tech-nologies. The highly fluorescent adenine analogue 2 aminopurine (2AP) is still the most used within the few hundreds of newly FBAs synthesized, but its excitation in the UV region demands for high energy sources endanger-ing living cells. New and highly fluorescent 2AP deriva-tives, 2-amino-6-cyanopu...
Bovine lactoferrin-loaded plasmonic magnetoliposomes for antifungal therapeutic...
Pereira, Mélanie; Rodrigues, Ana Rita Oliveira; Amaral, Leslie; Côrte-Real, Manuela; Pereira, Cátia Sofia Santos; Castanheira, Elisabete M. S.Bovine lactoferrin (bLf) is a milk-derived protein that exhibits potent broad-spectrum antifungal activity against multiple fungi. bLf is susceptible to degradation, while some of its properties depend on the tertiary structure. So, the encapsulation of bLf in stimuli-responsive therapeutic formulations provides an added value to enhance its biological activities. Plasmonic magnetoliposomes (PMLs) arise as prom...
Magnetoliposomes with calcium-doped magnesium ferrites anchored in the lipid su...
Cardoso, Beatriz Dias; Fernandes, Diana E. M.; Amorim, Carlos O.; Amaral, Vítor S.; Coutinho, Paulo J. G.; Rodrigues, Ana Rita OliveiraNanotechnology has provided a new insight into cancer treatment by enabling the development of nanocarriers for the encapsulation, transport, and controlled release of antitumor drugs at the target site. Among these nanocarriers, magnetic nanosystems have gained prominence. This work presents the design, development, and characterization of magnetoliposomes (MLs), wherein superparamagnetic nanoparticles are cou...