2 documents found, page 1 of 1
The Duration of Stress Determines Sex Specificities in the Vulnerability to Dep...
Gaspar, Rita; Soares-Cunha, Carina; Domingues, Ana Verónica; Coimbra, Bárbara; Baptista, Filipa; Pinto, Luísa; Ambrósio, António; Rodrigues, Ana-JoãoStress exposure has been shown to induce a variety of molecular and functional alterations associated with anxiety and depression. Some studies suggest that microglia, the immune cells of the brain, play a significant role in determining neuronal and behavioral responses to chronic stress and also contribute to the development of stress-related psychopathologies. However, little is known about the impact of the...
NEDD8: A new ataxin-3 interactor
Ferro, Anabela; Carvalho, Ana Luísa; Teixeira-Castro, Andreia; Almeida, Carla; Tomé, Ricardo J.; Cortes, Luísa; Rodrigues, Ana-João; Logarinho, ElsaMachado-Joseph disease (MJD/SCA3) is an autosomal dominant neurodegenerative disease caused by the expansion of a CAG tract in the coding portion of the ATXN3 gene. The presence of ubiquitin-positive aggregates of the defective protein in affected neurons is characteristic of this and most of the polyglutamine disorders. Recently, the accumulation of the neural precursor cell expressed developmentally downregul...