Intracytoplasmic sperm injection (ICSI) is a widely used technique in fertility centers. ICSI success depends on both nuclear and cytoplasmic oocyte maturation. Cumulus cells, which surround the oocytes, play a pivotal role in oocyte competence. However, the significance of DNA damage in cumulus cells as a marker of fertilization success remains largely unexplored. This study aims to investigate the relationshi...
Objective: Analysis of the results of mastoidectomy using the retrograde technique for removal of cholesteatomas in adults. Methods: Retrospective analysis of cases of mastoidectomy via retrograde technique performed at Centro Hospitalar Tondela-Viseu between January 2018 and December 2021 with collection of demographic data, type of surgery, reconstruction of the posterosuperior wall of the canal, type of tymp...
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Introduction: Intracytoplasmic sperm injection (ICSI) is currently used in clinical practice for couples with fertility issues. Some studies have shown an association between male reproductive ability and sperm DNA damage levels, assessed by comet assay. However, little is known regarding this endpoint and female fertility, mostly due to tissue accessibility. To overcome this, we used cumulus cells (CC) to anal...
More than 50 causes of pleural effusion are known and, although the majority are benign (85%), both malignant and unknown causes are common. [...]
O objetivo deste trabalho é apresentar o projeto Mudamente, que consiste em uma iniciativa de mentoria aplicada ao desenvolvimento da autonomia e do protagonismo estudantil. O projeto traz como pressupostos teóricos a aprendizagem baseada em projetos, conforme Bender (2000), bem como os princípios básicos das metodologias ativas na perspectiva de Bransford et al (2000) e Pilati (2017), a saber, (i) a valorizaçã...
The polymorphic trinucleotide repetitive region in the FMR1 gene 5'UTR contains AGG interspersions, particularly in normal-sized alleles (CGG < 45). In this range repetitive stretches are typically interrupted once or twice, although alleles without or with three or more AGG interspersions can also be observed. AGG interspersions together with the total length of the repetitive region confer stability and hinde...