14 documents found, page 1 of 2
Bone mechanical stimulation with piezoelectric materials
Reis, J; Frias, C; Capela e Silva, F; Potes, J; Simões, JA; Botelho, MI; Castro, CC; Marques, ATThis chapter summarized explores in vivo use of a piezoelectric polymer for bone mechanical stimulation
A new piezoelectric actuator induces bone formation in vivo: a preliminary study
Reis, J; Frias, C; Canto e Castro, C; Botelho, ML; Marques, AT; Simões JA, JA; Capela e Silva, F; Potes, JThis in vivo study presents the preliminary results of the use of a novel piezoelectric actuator for orthopedic application. The innovative use of the converse piezoelectric effect to mechanically stimulate bone was achieved with polyvinylidene fluoride actuators implanted in osteotomy cuts in sheep femur and tibia. The biological response around the osteotomies was assessed through histology and histomorphomet...
Piezoelectric actuators for bone mechanical stimulation: exploring the concept.
Reis, J; Frias, C; Capela e Silva, F; Potes, J; Botelho, ML; Canto e Castro, C; Marques, AT; Simões, JAArthroplasty is liable to cause intense changes on strain levels and distribution in the boné surrounding the implant, namely stress shielding. Several solutions have been proposed for this, namely design variations and development of controlled-stiffness implants. A new approach to this problem, with potential application to other orthopaedic problems and other medical fields, would be the development of smart...
Effect of condensed tannin ingestion in sheep and goat parotid saliva proteome
Lamy, E; da Costa, G; Santos, R; Capela e Silva, F; Potes, J; Pereira, A; Coelho, AV; Sales Baptista, ESaliva appears as a defence mechanism, against potential negative effects of tannins, in some species of animals which have to deal with these plant secondary metabolites in their regular diets. This study was carried out to investigate changes in parotid saliva protein profiles of sheep Ovis aries)and goats (Capra hircus), induced by condensed tannin ingestion. Five Merino sheep and five Serpentina goats were ...
Expressão da caderina na discondroplasia tibial
Capela e Silva, F; Lamy, E; Pereira, A; Potes, J; Cabrita, ASBy immunohistochemistry the expression of a pan-cadherin antibody that recognizes a wide variety of cadherins in chondrocytes from normal and tibial dyschondroplasia (TD) growth plates was compared. Surprisingly, an upregulated expression that was not expected in TD lesion chondrocytes was observed. The reason for this apparent upregulation is not clear. The increased expression may simply be due to the particu...
Expressão imunoistoquímica da proteína S-100 na discondroplasia da tíbia
Capela e Silva, F; Lamy E, E; Reis, J; Potes, J; Pereira, A; Cabrita AS, ASIt was compared, by immunohistochemistry, the expression of S-100 protein from normal and tibial dyschondroplasia (TD) growth plates. The results suggest that S-100 may be involved in growth plate homeostasis. The expression of S-100 in dyschondroplastic chondrocytes may be due to a low level of calcium in the lesion and/or compression of chondrocytes by the accumulated matrix. One further possibility is the as...
Piezoelectric actuator: searching inspiration in nature for osteoblast stimulation
Frias, C; Reis, J; Capela e Silva, F; Potes, J; Simões, J; Marques, ATBone is a composite with piezoelectric properties. Bone mass and structure are dependent on mechanical stress and adaptive response at cellular and tissue levels, but the role piezoelectricity plays in bone physiology is yet to be understood. Physical activity enhances bone density, through mechanical stimulation. Osteocytes and osteoblasts are essential for mechanosensing and mechanotransduction. Strategies ha...
Polymeric piezoelectric actuator substrate for osteoblast mechanical stimulation.
Frias, C; Reis, J; Capela e Silva, F; Potes, J; Simões, J; Marques, ATBone mass distribution and structure are dependent on mechanical stress and adaptive response at cellular and tissue levels. Mechanical stimulation of bone induces new bone formation in vivo and increases the metabolic activity and gene expression of osteoblasts in culture. A wide variety of devices have been tested for mechanical stimulation of cells and tissues in vitro. The aim of this work was to experiment...
In vitro studies of multiwalled carbon nanotube/ultrahigh molecular weight poly...
Reis, J; Kanagaraj, S; Fonseca, A; Mathew, MT; Capela e Silva, F; Potes, J; Pereira, A; Oliveira, MAS; Simões, JCarbon nanotubes are highly versatile materials; new applications using them are continuously being developed. Special attention is being dedicated to the possible use of multiwalled carbon nanotubes in biomaterials contacting with bone. However, carbon nanotubes are also controversial in regards to effects exerted on living organisms. Carbon nanotubes can be used to improve the tribological properties of polym...
Integrated biomimetic carbon nanotube composites for in vivo systems.
Kumar Singh, MK; Gracio, J; LeDuc, P; Gonçalves, PP; Marques, P; Gonçalves, G; Marques, F; Silva, VS; Capela e Silva, F; Reis, J; Potes, J; Sousa, AAs interest in using carbon nanotubes for developing biologically compatible systems continues to grow, biological inspiration is stimulating new directions for in vivo approaches. The ability to integrate nanotechnology-based systems in the body will provide greater successes if the implanted material is made to mimic elements of the biological milieu especially through tuning physical and chemical characteris...