8 documents found, page 1 of 1
Knowledge transfer through digital education technologies in higher education
Sousa, M. J.; Rosa, L. A. B. da.; Rodrigues, C. M.; Campos, W. Y. Y. Z.; Costa, J. M.Education is essential for the development of skills and talents that enable people to be productive citizens and active members of society. Traditional modes of education, on the other hand, are no longer enough to fulfill society's complex expectations, as people frequently change occupations, seek new educational possibilities, and struggle to manage life, work, and compete for educational demands (Houlden &...
Isoflavones as apoptosis inducers in human hepatoma HuH-7 cells.
Mansoor, T.A.; Ramalho, R.M.; Luo, X.; Ramalhete, Cátia; Rodrigues, C. M.; Ferreira, Maria JoséNine flavonoids isolated from the ethyl acetate extract of Pycnanthus angolensis were assayed for their potential apoptosis induction activities in human hepatoma HuH-7 cells. These flavonoids include eight isoflavones, namely irilone (1), tectorigenine (2), formononetin (3), genistein (4), 2'-hydroxybiochanin A (5), mixture of biochanin A (6) and prunetin (7), and 4',7-dihydroxy-2'-methoxyisoflavan (8), and th...
Interactions lake-atmosphere: the ALEX 2014 field campaign and numerical simula...
Salgado, R.; Potes, M.; Albino, A.; Apolinário, J.; Barbosa, S.; Bárias, S.; Beliche, P.; Bortoli, D.; Canhoto, P.; Costa, M. J.; Fernandes, R.M.The ALqueva hydro-meteorological EXperiment, ALEX 2014, was an integrated field campaign with measurements of chemical, physical and biological parameters in water and air at different experimental sites in the region of the Alqueva reservoir, a 250 km2 man made lake, in the southeast of Portugal. The Field campaign took place from June 1 to September 30, 2014 and comprises an Intensive Observation Period (IOP)...
The Alqueva hydro-meteorologic experiment
Salgado, R.; Potes, M.; Albino, A.; Apolinário, J.; Barbosa, S.; Bárias, S.; Beliche, P.; Bortoli, D.; Canhoto, P.; Costa, M. J.; Fernandes, R.M.The ALqueva hydro-meteorological experiment, ALEX 2014 (http://www.alex2014.cge.uevora.pt) was an integrated field campaign with measurements of chemical, physical and biological parameters at different experimental sites in the Alqueva reservoir and in its surrounding region. With the main purpose of studing the lake-atmosphere interactions, the ALEX 2014 took place form June to September and comprised a three...
Cholesterol 24S-Hydroxylase overexpression inhibits the liver X receptor (LXR) ...
Moutinho, Miguel; Nunes, Maria João; Gomes, Anita Q.; Gama, Maria João; Cedazo-Minguez, Angel; Rodrigues, C. M.; Björkhem, Ingemar; Rodrigues, ElsaThe neuronal-specific cholesterol 24S-hydroxylase (CYP46A1) is important for brain cholesterol elimination. Cyp46a1 null mice exhibit severe deficiencies in learning and hippocampal long-term potentiation, suggested to be caused by a decrease in isoprenoid intermediates of the mevalonate pathway. Conversely, transgenic mice overexpressing CYP46A1 show an improved cognitive function. These results raised the que...
Role of miR-21 in regenerating rat liver
Castro, R. E.; Santos, D. M.; Zeng, Y.; Steer, C. J.; Rodrigues, C. M.; Kren, B. T.
Differential regulation of cyclin D1 and apoptosis by bile acids in primary rat...
Castro, R. E.; Amaral, J. D.; Sola, S.; Kren, B. T.; Steer, C. J.; Rodrigues, C. M.
P53 is a specific molecular target of ursodeoxycholic acid
Amaral, J. D.; Castro, R. E.; Sola, S.; Rodrigues, C. M.