10 documents found, page 1 of 1
Pharmacological treatment of COPD - New evidence
Pires, N.; Pinto, P. G. N.; Marçal, N; Ferreira, A. J.; Rodrigues, C. M. P.; Bárbara, CChronic Obstructive Pulmonary Disease (COPD) is currently the 4th leading cause of death worldwide but is projected to be the 3rd leading cause of death by 2020. In Portugal, the estimated prevalence of COPD in the Lisbon region is 14.2%, and a large proportion of underdiagnosed disease has been detected. In 2016, a Portuguese panel of experts proposed pharmacological treatment approaches to COPD based on the e...
Tauroursodeoxycholic acid protects retinal neural cells from cell death induced...
Gaspar, J. M.; Martins, A.; Cruz, R.; Rodrigues, C. M. P.; Ambrósio, A. F.; Santiago, A. R.Diabetic retinopathy is one of the most frequent causes of blindness in adults in the Western countries. Although diabetic retinopathy is considered a vascular disease, several reports demonstrate that retinal neurons are also affected, leading to vision loss. Tauroursodeoxycholic acid (TUDCA), an endogenous bile acid, has proven to be neuroprotective in several models of neurodegenerative diseases, including m...
Monoterpene indole alkaloids from the leaves of Tabernaemontana elegans induce ...
Mansoor, T. A.; Ramalho, R. M.; Rodrigues, C. M. P.; Mulhovo, S.; Ferreira, M. J. U.
Tauroursodeoxycholic acid prevents E22Q Alzheimer's A beta toxicity in human ce...
Viana, R. J. S.; Nunes, A. F.; Castro, R. E.; Ramalho, R. M.; Meyerson, J.; Fossati, S.; Ghiso, J.; Rostagno, A.; Rodrigues, C. M. P.The vasculotropic E22Q mutant of the amyloid-beta (A beta) peptide is associated with hereditary cerebral hemorrhage with amyloidosis Dutch type. The cellular mechanism(s) of toxicity and nature of the A beta E22Q toxic assemblies are not completely understood. Comparative assessment of structural parameters and cell death mechanisms elicited in primary human cerebral endothelial cells by A beta E22Q and wild-t...
MODULATION OF MIRNAS BY BILE ACIDS
Castro, R. E.; Zeng, Y.; Steer, C. J.; Kren, B. T.; Rodrigues, C. M. P.
MODULATION OF THE P53 UBIQUITIN-PROTEASOME DEGRADATION PATHWAY BY URSODEOXYCHOL...
Amaral, J. D.; Castro, R. E.; Sola, S.; Rodrigues, C. M. P.
Ursodeoxycholic acid modulates the ubiquitin-proteasome degradation pathway of P53
Amaral, J. D.; Castro, R. E.; Sola, S.; Rodrigues, C. M. P.
NF-kappa B and apoptosis in colorectal tumourigenesis
Aranha, M. M.; Borralho, P. M.; Ravasco, P.; da Silva, I. B. Moreira; Correia, L.; Fernandes, A.; Camilo, M. E.; Rodrigues, C. M. P.Background Nuclear factor-kappa B (NF-kappa B) may play an important role in colorectal tumourigenesis, controlling cell cycle and apoptosis gene expression. In addition, imbalances between cell proliferation and cell death are thought to underlie neoplas
Progesterone and caspase-3 activation in equine cyclic corpora lutea
Ferreira-Dias, G.; Mateus, L.; Costa, A. S.; Sola, S.; Ramalho, R. M.; Castro, R. E.; Rodrigues, C. M. P.Soon after ovulation, the newly formed corpus luteum (CL) starts secreting progesterone (P-4), necessary for implantation. The CL, an ovarian transient endocrine organ, undergoes growth and regression throughout its life span. The objective of this study
Bile acids differentally regulate cell cycle and apoptosis-related proteins in ...
Castro, R. E.; Amaral, J. D.; Borralho, P.; Sola, S.; Kren, B. T.; Steer, C. J.; Rodrigues, C. M. P.