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Alterations in mucosa branched N-glycans lead to dysbiosis and downregulation o...
Rodrigues, CS; Gaifem, J; Pereira, MS; Alves, MF; Silva, M; Padrão, N; Cavadas, B; Moreira-Barbosa, C; Alves, I; Marcos-Pinto, R; Torres, J; Lavelle, AThe perturbation of the symbiotic relationship between microbes and intestinal immune system contributes to gut inflammation and Inflammatory Bowel Disease (IBD) development. The host mucosa glycans (glycocalyx) creates a major biological interface between gut microorganisms and host immunity that remains ill-defined. Glycans are essential players in IBD immunopathogenesis, even years before disease onset. Howe...
The role of glycans in health and disease: Regulators of the interaction betwee...
Crouch, LI; Rodrigues, CS; Bakshani, CR; Tavares-Gomes, L; Gaifem, J; Pinho, SSThe human gut microbiota is home to a diverse collection of microorganisms that has co-evolved with the host immune system in which host-microbiota interactions are essential to preserve health and homeostasis. Evidence suggests that the perturbation of this symbiotic host-microbiome relationship contributes to the onset of major diseases such as chronic inflammatory diseases including Inflammatory Bowel Diseas...
A unique serum IgG glycosylation signature predicts development of Crohn’s dise...
Gaifem, J; Rodrigues, CS; Petralia, F; Alves, I; Leite-Gomes, E; Cavadas, B; Dias, AM; Moreira-Barbosa, C; Revés, J; Laird, RM; Novokmet, M; Štambuk, JInflammatory bowel disease (IBD) is characterized by chronic inflammation in the gut. There is growing evidence in Crohn’s disease (CD) of the existence of a preclinical period characterized by immunological changes preceding symptom onset that starts years before diagnosis. Gaining insight into this preclinical phase will allow disease prediction and prevention. Analysis of preclinical serum samples, up to 6 y...