2 documents found, page 1 of 1
Inhibition of receptor-interacting protein kinase 1 improves experimental non-a...
Majdi, Amine; Aoudjehane, Lynda; Ratziu, Vlad; Islam, Tawhidul; Afonso, Marta B; Conti, Filomena; Mestiri, Taïeb; Lagouge, Marie; Foufelle, FabienneIn non-alcoholic fatty liver disease (NAFLD), hepatocytes can undergo necroptosis: a regulated form of necrotic cell death mediated by the receptor-interacting protein kinase (RIPK) 1. Herein, we assessed the potential for RIPK1 and its downstream effector mixed lineage kinase domain-like protein (MLKL) to act as therapeutic targets and markers of activity in NAFLD.
Release of cytochrome C with the interaction of bilirubin, amyloid beta-peptide...
Solá, Susana; Diógenes, Maria José; Brites, Dora; Rodrigues, Cecília M PThe pathogenesis of cholestasis, bilirubin encephalopathy, and Alzheimer's disease appears to result from accumulation of diverse cytotoxic agents, which in turn may cause apoptotic cell death. In addition, mitochondria has lately been considered as a central executioner of programmed cell death, through the release of caspase activating factors. The aims of this study were to: (a) investigate mitochondrial per...