4 documents found, page 1 of 1
Induced autolysis of engineered yeast residue as a means to simplify downstream...
Fundo, Joana F.; Deuchande, Teresa; Rodrigues, Daniela A.; Pimentel, Lígia L.; Vidigal, Susana S. M. P.; Rodríguez-Alcalá, Luís M.; Pintado, Manuela E.The objective of this work was to study the efficiency of different autolysis processes, combining different temperatures and pH conditions, when applied to a genetically engineered yeast residue. The determination of the supernatants’ dry weight showed that the autolysis time could be reduced to half, from 4 to 2 h, if the residue pH was increased from 5 to 8 at 50 °C (18.20% for 4 h and 18.70% for 2 h with a ...
Operationalisation for Portugal of the EU(7)-PIM List for Identification of Pot...
Rodrigues, Daniela A.; Herdeiro, Maria T.; Thürmann, Petra A.; Figueiras, Adolfo; Coutinho, Paula; Roque, FátimaIntroduction: In 2015, the EU(7)-PIM List was published, which identifies potentially inappropriate medicines in older patients and resulted from a consensus of experts from seven European countries. Portugal was not part of this group, so it was not originally adapted to the Portuguese reality. With this work, we intend to elaborate a list of potentially inappropriate medicines adapted to the reality of medici...
Antibiotic dispensation without a prescription worldwide: a systematic review
Batista, Ana Daniela; Rodrigues, Daniela A.; Figueiras, Adolfo; Zapata-Cachafeiro, Maruxa; Roque, Fátima; Herdeiro, Maria TeresaAntibiotic resistance still remains a major global public health problem and the dispensing of antibiotics without a prescription at community pharmacies is an important driver of this. MEDLINE, Pubmed and EMBASE databases were used to search and identify studies reporting the dispensing of non-prescribed antibiotics in community pharmacies or drugstores that sell drugs for human use, by applying pharmacy inter...
Elderly and polypharmacy: physiological and cognitive change
Rodrigues, Daniela A.; Herdeiro, Maria Teresa; Figueiras, Adolfo; Coutinho, Paula; Roque, FátimaPopulation ageing is one of the most significant social transformations of the twenty-first century. The increase in average life expectancy was a successful challenge achieved in the modern world. However, nowadays a new challenge arises for all society: achieving a better quality of life for increasing people’s life. The comorbidities associated with ageing make elderly prone to polypharmacy. On the other han...