67 documents found, page 1 of 7
Development of an in vitro skin cell model and comparison with ex vivo models: ...
Marques, Mariana; Teixeira, Filipa; Vieira, Mónica; Rodrigues, Francisca; Vieira, MónicaSkin is the first physical barrier against pathogens and mechanical injuries, and stratum corneum, the outermost layer of the skin, is the primary barrier to therapeutic delivery. Skin is divided into the epidermis, which consists mainly of keratinocytes and the dermis, composed of fibroblasts, and extracellular matrix components. Skin models are crucial for assessing the safety and efficacy of cosmetic ingredi...
Unraveling the nutraceutical potential of Salicornia ramosissima by-product – i...
Pinto, Diana; Santos, Inês; Delerue-Matos, Cristina; Teixeira, Filipa; Sut, Stefania; Dall’Acqua, Stefano; Vieira, Mónica; Rodrigues, FranciscaSalicornia ramosissima by-product (SP) is an underexploited antioxidant-rich by-product. This study explored the phytochemical profile, bioaccessibility, and biological activity of SP before and after extraction (SBE and SAE, respectively) upon gastrointestinal simulated digestion and intestinal permeability. The phenolic and flavonoid concentrations increased during digestion, reaching bioaccessibility rates a...
Ultrasound-assisted extraction of bioactive compounds from goji berries: optimi...
Teixeira, Filipa; Silva, Ana Margarida; Sut, Stefania; Dall'Acqua, Stefano; Ramos, Oscar L.; Ribeiro, Alessandra B.; Ferraz, RicardoLycium barbarum L. berries have a remarkable chemical composition and extensive biological activities, being a valuable component of health and nutraceutical practices. Nevertheless, a deep insight on the intestinal permeation of the pro-healthy bioactive compounds is urgently needed to predict the real effects on human body. This study attempted, for the first time, to optimize the Ultrasound-Assisted Extracti...
Insights into the bioactive composition, antioxidant properties and In vitro ce...
Silva, Ana Margarida; Moreira, Manuela M.; Teixeira, Filipa; Delerue-Matos, Cristina; Rodrigues, Francisca; Ferraz, Ricardo; Salazar, MiguelDisphyma crassifolium, commonly known as sea fingers, is a halophyte plant recently introduced in gourmet cuisine. The present study aims to extract the bioactive compounds of D. crassifolium using ultrasound-assisted extraction and employing green solvents (water and ethanol). The antioxidant/antiradical activities, scavenging capacity against reactive species, phenolic profile, and intestinal effects were eva...
Ultrasound-assisted extraction of bioactive compounds from goji berries: Optimi...
Teixeira, Filipa; Silva, Ana Margarida; Sut, Stefania; Dall’Acqua, Stefano; Ramos, Oscar L.; Ribeiro, Alessandra B.; Ferraz, Ricardovaluable component of health and nutraceutical practices. Nevertheless, a deep insight on the intestinal permeation of the pro-healthy bioactive compounds is urgently needed to predict the real effects on human body. This study attempted, for the first time, to optimize the Ultrasound-Assisted Extraction (UAE) of goji berries using a Response Surface Methodology approach and establish the intestinal permeation ...
Goji berries (Lycium barbarum) extract as new potential cosmetic ingredient – A...
Silva, Joana; Teixeira, Filipa; Silva, Ana M.; Vieira, Mónica; Amaral, M. Helena; Rodrigues, Francisca; Vieira, MónicaCurrently there is greater concern about appearance and skin care products. Although cosmetic products are not associated with serious health problems, there are concerns related to undesirable effects due to the presence of potentially carcinogenic and allergenic ingredients. Thus, consumers have been increasingly looking for products of natural and plant-based origin. The use of these products is expected to ...
Development of enhanced buccal films with Actinidia arguta fruit extract for or...
Teixeira, Filipa; Silva, Ana Margarida; Macedo, Catarina; Estevinho, Berta; Sut, Stefania; Dall’Acqua, Stefano; Delerue-Matos, Cristina; Costa, Paulo C.Background: Oral mucositis (OM) is a common side effect of cancer treatments such as chemotherapy [1], being characterized by disruption of the oral mucosa integrity, inflammation, and pain [1,2]. The treatment strategies to prevent and treat OM are still unsatisfactory, leading to the search of new active compounds, particularly from natural sources, such as Actinidia arguta fruits [1]. A. arguta fruit, c...
Are tomato plants co-exposed to heat and salinity able to ensure a proper carbo...
Rodrigues, Francisca; Sousa, Bruno; Soares, Cristiano; Moreira, Diana; Pereira, Cláudia; Moutinho-Pereira, José; Cunha, Ana; Fidalgo, FernandaAbiotic stress combinations, such as high temperatures and soil/water salinization, severely threaten crop productivity worldwide. In this work, an integrative insight into the photosynthetic metabolism of tomato plants subjected to salt (100 mM NaCl) and/or heat (42 °C; 4 h/day) was performed. After three weeks, the stress combination led to more severe consequences on growth and photosynthetic pigments than t...
Riluzole-loaded lipid nanoparticles for brain delivery: preparation, optimizati...
Teixeira, Maria Inês; Lopes, Carla Martins; Gonçalves, Hugo; Catita, José; Silva, Ana Margarida; Rodrigues, Francisca; Amaral, Maria HelenaAmyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease, with a median survival of only 2 to 4 years. Riluzole, a drug commonly used in the management of ALS, has a low aqueous solubility and limited bioavailability. ALS treatment is also hindered by the presence of the blood–brain barrier (BBB) that preserves the delicate homeostasis of the cerebral milieu, isolating it and making brain drug d...
Development and Characterization of Functional Cookies Enriched with Chestnut S...
Pinto, Diana; Moreira, Manuela M.; Vieira, Elsa F.; Švarc-Gajić, Jaroslava; Vallverdú-Queralt, Anna; Brezo-Borjan, Tanja; Delerue-Matos, CristinaChestnut (Castanea sativa) shells (CSs), an undervalued agro-industrial biowaste, have arisen as a source of bioactive compounds with promising health-promoting effects. This study attempted, for the first time, to develop a functional food, namely cookies, using a CS extract obtained by an eco-friendly technology (subcritical water extraction). The cookies were characterized regarding their nutritional composi...