14 documents found, page 1 of 2

Laminin-α2 chain deficiency in skeletal muscle causes dysregulation of multiple...

LAMA2, coding for the laminin-α2 chain, is a crucial ECM component, particularly abundant in skeletal muscle. Mutations in LAMA2 trigger the often-lethal LAMA2-congenital muscular dystrophy (LAMA2-CMD). Various phenotypes have been linked to LAMA2-CMD; nevertheless, the precise mechanisms that malfunction during disease onset in utero remain unknown. We generated Lama2-deficient C2C12 cells and found that Lama2...

Preparation of 3D Decellularized Matrices from Fetal Mouse Skeletal Muscle for ...

The extracellular matrix (ECM) plays a crucial role in providing structural support for cells and conveying signals that are important for various cellular processes. Two-dimensional (2D) cell culture models oversimplify the complex interactions between cells and the ECM, as the lack of a complete three-dimensional (3D) support can alter cell behavior, making them inadequate for understanding in vivo processes....

Review of Piezoelectrical Materials Potentially Useful for Peripheral Nerve Repair

It has increasingly been recognized that electrical currents play a pivotal role in cell migration and tissue repair, in a process named “galvanotaxis”. In this review, we summarize the current evidence supporting the potential benefits of electric stimulation (ES) in the physiology of peripheral nerve repair (PNR). Moreover, we discuss the potential of piezoelectric materials in this context. The use of these ...

Circuito Verde Regional Barreiro: estudo de caso Parque Ecológico Padre Alfredo...

O circuito verde é uma proposta de Requalificação Urbana Sustentável, que visa promover uma integração das áreas verdes da Regional Barreiro e seu entorno, promovendo mobilidade, esporte e lazer aos cidadãos de forma homogênea e democrática pela regional. Propõe-se a reestruturação dos parques, potencializando-os e uma conexão entre as áreas verdes disponíveis com arborização e infraestrutura. Sendo apresentado...

Chitosan-Based Membranes for Skin Wound Repair in a Dorsal Fold Chamber Rat Model

Frequently, deep partial and full-thickness skin wounds do not spontaneously regenerate. To restore the normal function of skin, epidermal and dermal components have to be supplied to the wound bed by grafting various substrates. Available options are limited and frequently costly. Herein, authors present a possible approach using 3D skin scaffolds capable of mimicking structure and biological functions of the ...

Chitosan/PVA Based Membranes Processed by Gamma Radiation as Scaffolding Materi...

Some of the current strategies for the development of scaffolding materials capable of inducing tissue regeneration have been based on the use of polymeric biomaterials. Chitosan, in particular, due to its recognized biological activity has been used in a number of biomedical applications. Aiming the development of chitosan-based membranes with improved cell adhesion and growth properties to be used as skin sca...

Letter About “Seven Years of Febrile Neutropenia in Internal Medicine Department”

Relatório de estágio curricular supervisionado: clínica médica e cirúrgica de p...

TCC (graduação) - Universidade Federal de Santa Catarina. Campus Curitibanos. Medicina Veterinária.; O estágio supervisionado obrigatório em Medicina Veterinária permite aos acadêmicos a oportunidade de praticar as lições aprendidas durante a graduação e prepará-los para a próxima etapa de suas vidas, o mercado de trabalho. A Clínica Médica e Cirurgica de Pequenos Animais é um dos setores que mais demandam prof...

A complex scenario of tuberculosis transmission is revealed through genetic and...

Tuberculosis (TB) incidence is decreasing worldwide and eradication is becoming plausible. In low-incidence countries, intervention on migrant populations is considered one of the most important strategies for elimination. However, such measures are inappropriate in European areas where TB is largely endemic, such as Porto in Portugal. We aim to understand transmission chains in Porto through a genetic characte...

Chitosan/Poly(vinylpyrrolidone) Matrices Obtained by Gamma-Irradiation for Skin...

Several studies have shown that chitosan possesses characteristics favorable for promoting dermal regeneration and accelerated wound healing. In this work we have reported the work that has been done on the development and characterization of biocompatible and biodegradable chitosan based matrices to be used as skin scaffolds. Poly(vinylpyrrrolidone) (PVP) was used as copolymer and a two steps methodology of fr...