52 documents found, page 1 of 6

Practical Guidance on the Detection of NTRK Fusions in Sarcomas: Current Status...

Sarcomas are a rare and heterogeneous group of mesenchymal malignant tumors and account for approximately 1% of all adult cancers and around 20% of all pediatric solid tumors in Europe. Technology advances have enabled a more accurate and efficient characterization of the molecular mechanisms underlying the pathogenesis of sarcoma subtypes and revealed novel and unexpected therapeutic targets with prognostic/pr...

Epidemiological and Clinical Aspects of Cutaneous and Mucosal Leishmaniases in ...

Leishmania infantum, a zoonotic vector-born parasite, is endemic in the Mediterranean region, presenting mostly as visceral (VL), but also as cutaneous (CL) and mucosal leishmaniasis (ML). This study aimed to describe the epidemiological and clinical aspects of the CL and ML cases diagnosed in mainland Portugal between 2010 and 2020. Collaboration was requested from every hospital of the Portuguese National Hea...

Epidemiological and Clinical Aspects of Cutaneous and Mucosal Leishmaniases in ...

Leishmania infantum, a zoonotic vector-born parasite, is endemic in the Mediterranean region, presenting mostly as visceral (VL), but also as cutaneous (CL) and mucosal leishmaniasis (ML). This study aimed to describe the epidemiological and clinical aspects of the CL and ML cases diagnosed in mainland Portugal between 2010 and 2020. Collaboration was requested from every hospital of the Portuguese National Hea...

Endobronchial Amphotericin B to Treat Hemoptysis in an Inoperable Patient with ...

A 37-year-old man presented with chronic cavitary pulmonary aspergillosis and hemoptysis refractory to systemic antifungal therapy with voriconazole and bronchial artery embolization. Surgical excision was unfeasible due to the patient's refusal of blood transfusions. Ten sessions of intracavitary instillation of amphotericin B via flexible bronchoscopy were then performed. Hemoptysis cessation and aspergilloma...

Fostering the Ecosystem of Open Neural Encoders for Portuguese with Albertina P...

To foster the neural encoding of Portuguese, this paper contributes foundation encoder models that represent an expansion of the still very scarce ecosystem of large language models specifically developed for this language that are fully open, in the sense that they are open source and openly distributed for free under an open license for any purpose, thus including research and commercial usages. Like most lan...

Weight loss in patients with severe obesity after bariatric surgery–the potenti...

Background: Despite the potential effectiveness of bariatric surgery in promoting weight loss, a considerable proportion of patients still face the challenge of achieving optimal post-surgery outcomes. The timing of eating, in addition to the content of what is eaten, as well as chronotype and social jetlag (a marker of circadian misalignment), have been implicated in weight regulation. However, the current und...

PORTULAN ExtraGLUE Datasets and Models: Kick-starting a Benchmark for the Neura...

Leveraging research on the neural modelling of Portuguese, we contribute a collection of datasets for an array of language processing tasks and a corresponding collection of fine-tuned neural language models on these downstream tasks. To align with mainstream benchmarks in the literature, originally developed in English, and to kick start their Portuguese counterparts, the datasets were machine-translated from ...

Advancing Neural Encoding of Portuguese with Transformer Albertina PT-*

To advance the neural encoding of Portuguese (PT), and a fortiori the technological preparation of this language for the digital age, we developed a Transformer-based foundation model that sets a new state of the art in this respect for two of its variants, namely European Portuguese from Portugal (PT-PT) and American Portuguese from Brazil (PT-BR). To develop this encoder, which we named Albertina PT-*, a stro...

Advancing Neural Encoding of Portuguese with Transformer Albertina PT-

Diagnostic Challenge in a Sickle Cell Disease Patient with COVID-19

Acute chest syndrome is a life-threatening complication in sickle cell disease. Infections are frequently implied, and like other viruses, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may be a trigger. In addition, due to their inflammatory status, they may present a higher risk for severe coronavirus disease 2019 (COVID-19). Pneumonia and acute chest syndrome share clinical, laboratory, and rad...