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Urine metabolomics during a legume diet intervention suggests altered metabolic...

Ferreira, Helena; Duarte, Daniela; Rodrigues, João A.; Vasconcelos, Marta W.; Pinto, Elisabete; Gil, Ana M.

Given the general increase in legume consumption worldwide, there is a need to characterize the resulting human metabolic adaptations in order to demonstrate potential legume diet/health relationships. A nuclear magnetic resonance (NMR) metabolomics urine study was carried out on a small cohort (n = 18) to characterize the excretory effects of a pilot longitudinal 8-week legume-based dietary intervention. Despi...


Impact of Sea Warming and 17-α-Ethinylestradiol Exposure on the Lipid Metabolis...

Rodrigues, João A.; Bispo, Daniela S. C.; Silva, Mónica G.; Araújo, Rita; Soares, Amadeu M. V. M.; Freitas, Rosa; Gil, Ana M.

This paper reports on an NMR metabolomics study of lipophilic extracts of Ruditapes philippinarum clams exposed to the hormonal contaminant 17-α-ethinylestradiol (EE2), at 17 °C and 21 °C. The results reveal that exposure at 17 °C triggers a weak response at low EE2 concentrations, suggestive of a slight increase in membrane rigidity, followed by lipid metabolic stability at higher EE2 concentrations. On the ot...


Evaluation of beer deterioration by gas chromatography–mass spectrometry/multiv...

Rodrigues, João A.; Barros, António S.; Carvalho, Beatriz; Brandão, Tiago; Gil, Ana M.; Ferreira, António C. Silva

Beer stability is a major concern for the brewing industry, as beer characteristics may be subject to significant changes during storage. This paper describes a novel non-targeted methodology for monitoring the chemical changes occurring in a lager beer exposed to accelerated aging (induced by thermal treatment: 18 days at 45 degrees C), using gas chromatography-mass spectrometry in tandem with multivariate ana...


Evaluation of beer deterioration by gas chromatography-mass spectrometry/multiv...

Rodrigues, João A.; Barros, António S.; Carvalho, Beatriz; Brandão, Tiago; Gil, Ana M.; Silva Ferreira, Antonio C.

Beer stability is a major concern for the brewing industry, as beer characteristics may be subject to significant changes during storage. This paper describes a novel non-targeted methodology for monitoring the chemical changes occurring in a lager beer exposed to accelerated aging (induced by thermal treatment: 18 days at 45 ◦C), using gas chromatography–mass spectrometry in tandem with multivariate analysis (...


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