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Insights on microplastic contamination from municipal and textile industry effl...
Magalhães, Solange; Paciência, Daniel; Rodrigues, João M. M.; Lindman, Björn; Alves, Luís; Medronho, Bruno; Rasteiro, Maria da GraçaThe rampant use of plastics, with the potential to degrade into insidious microplastics (MPs), poses a significant threat by contaminating aquatic environments. In the present study, we delved into the analysis of effluents from textile industries, a recognized major source of MPs contamination. Data were further discussed and compared with a municipal wastewater treatment plant (WWTP) effluent. All effluent sa...
Self-supporting hyaluronic acid-functionalized G-quadruplex-based perfusable mu...
Sousa, Vera; Amaral, Adérito J. R.; Castanheira, Edgar J.; Marques, Igor; Rodrigues, João M. M.; Félix, Vítor; Borges, João; Mano, João F.Dynamic G-quadruplex supramolecular hydrogels have aroused great interest in a broad range of bioapplications. However, neither the development of native extracellular matrix (ECM)-derived natural biopolymer-functionalized G-quadruplex hydrogels nor their use to create perfusable self-supporting hydrogels has been explored to date, despite their intrinsic potential as carrier vehicles of therapeutic agents, or ...
Marine-origin polysaccharides-based free-standing multilayered membranes as sus...
Sousa, Cristiana F. V.; Monteiro, Luís P. G.; Rodrigues, João M. M.; Borges, João; Mano, João F.The layer-by-layer (LbL) assembly technology has been widely used to functionalise surfaces and precisely engineer robust multilayered bioarchitectures with tunable structures, compositions, properties, and functions at the nanoscale by resorting to a myriad of building blocks exhibiting complementary interactions. Among them, marine-origin polysaccharides are a sustainable renewable resource for the fabricatio...
Unveiling the assembly of neutral marine polysaccharides into electrostatic-dri...
Monteiro, Luís P. G.; Borges, João; Rodrigues, João M. M.; Mano, João F.Marine-origin polysaccharides, in particular cationic and anionic ones, have been widely explored as building blocks in fully natural or hybrid electrostatic-driven Layer-by-Layer (LbL) assemblies for bioapplications. However, the low chemical versatility imparted by neutral polysaccharides has been limiting their assembly into LbL biodevices, despite their wide availability in sources such as the marine enviro...
Bioinspired oxidation-resistant catechol-like sliding ring polyrotaxane hydrogels
Rial-Hermida, M. Isabel; Costa, Dora C. S.; Jiang, Lan; Rodrigues, João M. M.; Ito, Kohzo; Mano, João F.Adaptable hydrogels have been used in the biomedical field to address several pathologies, especially those regarding tissue defects. Here, we describe unprecedented catechol-like functionalized polyrotaxane (PR) polymers able to form hydrogels. PR were functionalized with the incorporation of hydroxypyridinone (HOPO) moieties into the polymer backbone, with a degree of substitution from 4 to 22%, depending on ...
Green approaches for extraction, chemical modification and processing of marine...
Sacramento, Margarida M. A.; Borges, João; Correia, Fernando J. S.; Calado, Ricardo; Rodrigues, João M. M.; Patrício, Sónia G.; Mano, João F.Over the past few decades, natural-origin polysaccharides have received increasing attention across different fields of application, including biomedicine and biotechnology, because of their specific physicochemical and biological properties that have afforded the fabrication of a plethora of multifunctional devices for healthcare applications. More recently, marine raw materials from fisheries and aquaculture ...
Partial coated stem cells with bioinspired silica as new generation of cellular...
Maciel, Marta M.; Correia, Tiago R.; Gaspar, Vítor M.; Rodrigues, João M. M.; Choi, Insung S.; Mano, J. F.The manipulation of cell surfaces in anchorage-dependent cells can help overcome difficulties presented during cell handling and application. Silica-based protective mechanisms existing in free-floating microorganisms may be used as inspiration for sustaining human cell survival in suspension. Gathering on this, herein human adipose-derived mesenchymal stem cells (hASCs) are partially coated with a hard silica ...
Extending the Functionality of Marine-origin Polysaccharides Through Chemical M...
Rodrigues, João M. M.; Castanheira, E. J.; Costa, D. C. S.; Rocha, D. H. A.; Borges, J.; Mano, J. F.Natural polysaccharides are a major class of biomacromolecules with a high degree of biocompatibility, biodegradability, and ability to mimic the natural extracellular matrix (ECM) microenvironment and, therefore, have been receiving increasing attention. Polysaccharides often exhibit interesting and advantageous properties, including bioactivity, different functional groups, and bioadhesive properties, as well...
Partial coated stem cells with bioinspired silica as new generation of cellular...
Maciel, Marta M.; Correia, Tiago R.; Gaspar, Vítor M.; Rodrigues, João M. M.; Choi, Insung S.; Mano, João F.The manipulation of cell surfaces in anchorage-dependent cells can help overcome difficulties presented during cell handling and application. Silica-based protective mechanisms existing in free-floating microorganisms may be used as inspiration for sustaining human cell survival in suspension. Gathering on this, herein human adipose-derived mesenchymal stem cells (hASCs) are partially coated with a hard silica ...
Phthalocyanine-functionalized magnetic silica nanoparticles as anion chemosensors
Rodrigues, João M. M.; Farinha, Andreia S. F.; Zhi Lin; Cavaleiro, José A. S.; Tomé, Augusto C.; Tomé, João P. C.Anionic species are one of the most common pollutants in residual and freshwaters. The presence of anthropogenic anions in water drastically increases the toxicity to living beings. Here, we report the preparation of a new optical active material based on tri(tosylamino)phthalocyanines grafted to ferromagnetic silica nanoparticles for anion detection and removal. The new unsymmetrical phthalocyanines (Pcs) prov...