4 documents found, page 1 of 1
Chitosan film as a replacement for conventional sulphur dioxide treatment of wh...
Rodrigues, Joao A.; Nunes, Cláudia; Coimbra, Manuel A.; Goodfellow, Brian J.; Gil, Ana M.Chitosan-genipin (Ch-Ge) films have been proposed for the replacement of sulfur dioxide (SO2) in white wines preservation to circumvent the adverse health consequences caused by SO2 intake. To assess the effects of different-sized Ch-Ge films (25 and 100 cm2) on wine composition compared to SO2-treated and untreated wines, nuclear magnetic resonance metabolomics was applied. Relative to SO2, 100 cm2 films induc...
N6-methyladenosine in poly(A) tails stabilize VSG transcripts
Viegas, Idálio; Macedo, Juan; Serra, Lúcia; De Niz, Mariana; Temporão, Adriana; Silva Pereira, Sara; Mirza, Aashiq H.; Bergstrom, Ed; Rodrigues, Joao A.RNA modifications are important regulators of gene expression1. In Trypanosoma brucei, transcription is polycistronic and thus most regulation happens post-transcriptionally2. N6-methyladenosine (m6A) has been detected in this parasite, but its function remains unknown3. Here we found that m6A is enriched in 342 transcripts using RNA immunoprecipitation, with an enrichment in transcripts encoding variant surfac...
Parasite glycobiology: a bittersweet symphony
Rodrigues, Joao A.; Acosta-Serrano, Alvaro; Aebi, Markus; Ferguson, Michael A. J.; Routier, Françoise H.; Schiller, Irene; Soares, SimãoHuman infections caused by parasitic protozoans and helminths are among the world's leading causes of death. More than a million people die each year from diseases like malaria and neglected tropical diseases like leishmaniasis, trypanosomiasis, and schistosomiasis. Patients also endure disabilities that cause lifelong suffering and that affect productivity and development. More insidiously, parasites generate ...
Bioactivity studies and chemical profile of the antidiabetic plant Genista tenera
Rauter, Amelia P.; Martins, Alice; Lopes, Rui; Ferreira, Joana; Serralheiro, Luisa M.; Araujo, Maria-Eduarda; Borges, Carlos; Justino, JorgeAim of the study: Genista tenera is a plant endemic to the island of Madeira and is used in folk medicine to control diabetes. In the present work we evaluate the anti hyperglycaemic activity of its n-butanol extract and determine its chromatographic prof. - The British Council and the Ministerio da Ciencia e do Ensino Superior ; Fundacao para a Ciencia e Tecnologia ; Thermo Finnigan's ; Analytical Chemistry Tr...