3 documents found, page 1 of 1
Lactoferricin Peptides Increase Macrophages' Capacity To Kill Mycobacterium avium
Silva, T; Moreira, AC; Nazmi, K; Moniz, T; Vale, N; Rangel, M; Gomes, P; Bolscher, JGM; Rodrigues, PN; Bastos, M; Gomes, MSMycobacterial infections cause a significant burden of disease and death worldwide. Their treatment is long, toxic, costly, and increasingly prone to failure due to bacterial resistance to currently available antibiotics. New therapeutic options are thus clearly needed. Antimicrobial peptides represent an important source of new antimicrobial molecules, both for their direct activity and for their immunomodulat...
Hepcidin-dependent regulation of erythropoiesis during anemia in a teleost fish...
Neves, JV; Caldas, C; Ramos, M; Rodrigues, PNAnemia is a common disorder, characterized by abnormally low levels of red blood cells or hemoglobin. The mechanisms of anemia development and response have been thoroughly studied in mammals, but little is known in other vertebrates, particularly teleost fish. In this study, different degrees of anemia were induced in healthy European sea bass specimens (Dicentrarchus labrax) and at pre-determined time points ...
Transcription factor NRF2 protects mice against dietary iron-induced liver inju...
Silva-Gomes, S; Santos, AG; Caldas, C; Silva, CM; Neves, JV; Lopes, J; Carneiro, F; Rodrigues, PN; Duarte, TLBACKGROUND & AIMS: The liver, being the major site of iron storage, is particularly exposed to the toxic effects of iron. Transcription factor NRF2 is critical for protecting the liver against disease by activating the transcription of genes encoding detoxification/antioxidant enzymes. We aimed to determine if the NRF2 pathway plays a significant role in the protection against hepatic iron overload.METHODS: Wil...