3 documents found, page 1 of 1
Presynaptic A2A adenosine receptors dampen CB1 cannabinoid receptor-mediated in...
Ferreira, S. G.; Gonçalves, F. Q.; Marques, J. M.; Tomé, Â. R.; Rodrigues, R. J.; Nunes-Correia, I.; Ledent, C.; Harkany, T.; Venance, L.; Cunha, R. A.Background and Purpose Both CB1 cannabinoid and A2A adenosine receptors (CB1Rs and A2ARs) control synaptic transmission at corticostriatal synapses, with great therapeutic importance for neurological and psychiatric disorders. A post-synaptic CB1R-A2AR interaction has already been unraveled, but the presynaptic A2AR-mediated control of presynaptic neuromodulation by CB1Rs remains to be defined. Since the cortic...
Anandamide and NADA bi-directionally modulate presynaptic Ca<sup>2+</sup> level...
Köfalvi, A.; Pereira, M. F.; Rebola, N.; Rodrigues, R. J.; Oliveira, C. R.; Cunha, R. A.Inhibitory CB1 cannabinoid receptors and excitatory TRPV1 vanilloid receptors are abundant in the hippocampus. We tested if two known hybrid endocannabinoid/endovanilloid substances, N-arachidonoyl-dopamine (NADA) and anandamide (AEA), presynapticaly increased or decreased intracellular calcium level ([Ca2+]i) and GABA and glutamate release in the hippocampus. Resting and K+-evoked levels of [Ca2+]i and the rel...
Purinergic P2 receptors trigger adenosine release leading to adenosine A2A rece...
Almeida, T.; Rodrigues, R. J.; Mendonça, A. de; Ribeiro, J. A.; Cunha, R. A.Electrophysiological recordings were used to investigate the effects of ATP analogues on [theta]-burst-induced long-term potentiation (LTP) in rat hippocampal slices. [alpha],[beta]-Methylene ATP ([alpha],[beta]-MeATP; 20 [mu]M) decreased LTP from 36±9% to 17±5%, an effect prevented by adenosine A1 receptor blockade in accordance with the localised catabolism of ATP analogues into adenosine, leading to adenosin...