63 documents found, page 1 of 7
A proof-of-concept study aiming for the integration of an optical biosensor in ...
Correia, Margarida O.; Sousa, Paulo Jorge Teixeira; Rodrigues, Raquel Oliveira; Minas, GraçaAlzheimer’s disease (AD), a progressive neurodegenerative disorder, is marked by the abnormal production of amyloid-beta (Aβ) fibrils, a key biomarker for diagnosis and illness monitoring. Advanced microfluidic devices, such as brain-on-a-chip (BoC), are innovative preclinical tools with the potential to revolutionize AD early diagnosis and treatment. However, existing BoCs face limitations, including challenge...
Recent advances and perspectives of MicroNeedles for biomedical applications
Maia, Renata Faria; Machado, Pedro; Rodrigues, Raquel Oliveira; Faustino, Vera Luísa Carreira; Schütte, Helmut; Gassmann, Stefan; Lima, Rui A.Microneedles (MN) technology has emerged as a transformative tool within the biomedical field, offering innovative solutions to challenges in drug delivery, diagnostics, and therapeutic applications. This review article provides an in-depth exploration of the diverse perspectives and applications of MNs, shedding light on their pivotal role in shaping the future of biomedical research and clinical practice. It ...
Optical sensor system to monitor the pH of circulating media on biomimetic micr...
Mendes, Fernando; Miranda, Inês Sofia Ferreira; Rodrigues, Raquel Oliveira; Ferreira, Gabriel Malheiro; Schütte, Helmut; Gassmann, StefanpH is a physiological parameter of great importance in biomedical research. For example, during cell growth process, pH is usually lowered due to the acidic metabolites released by the cells. This decrease on the pH value can affect biological processes and, consequently, affect the accuracy of the research. To monitor the pH changes along cell engineering experiments, cell culture media is usually complemented...
PDMS porous microneedles used as engineered tool in advanced microfluidic devic...
Maia, Renata Patrícia Faria; Sousa, Paulo Jorge Teixeira; Pinto, Vânia Cristina Gonçalves; Soares, Delfim; Lima, Rui Alberto Madeira MacedoThe advancement of organ-on-a-chip (OoC), as end-use preclinical tool, has been slackened with the techno logical and engineering challenges that in-situ real-time monitoring of physicochemical and biological param eters still represent. In this study, the envisioned solution to surpass this challenge is the integration of a microneedle (MN) patch into a microfluidic device to collect cell culture media directl...
Microneedles in advanced microfluidic systems: a systematic review throughout l...
Maia, Renata Patrícia Faria; Carvalho, Violeta Meneses; Lima, Rui; Minas, Graça; Rodrigues, Raquel OliveiraMicroneedles (MNs) have been widely used in biomedical applications for drug delivery and biomarker detection purposes. Furthermore, MNs can also be used as a stand-alone tool to be combined with microfluidic devices. For that purpose, lab- or organ-on-a-chip are being developed. This systematic review aims to summarize the most recent progress in these emerging systems, to identify their advantages and limitat...
Development and characterization of porous PDMS microneedles
Maia, Renata Patrícia Faria; Sousa, Paulo Jorge Teixeira; Pinto, Vânia Cristina Gonçalves; Lima, Rui Alberto Madeira Macedo; Minas, GraçaThis study aimed the development and characterization of polydimethylsiloxane (PDMS) porous microneedles (MNs) cast with silica nanoparticles as porogenic material for biomedical applications. To produce the porous PDMS MNs, different concentrations of silica nanoparticles were cast into PDMS, followed by chemical etching to remove the casted material and produce a porogenic network. This chemical etching was a...
Editorial: Disease-on-a-chip: from point-of-care to personalized medicine
Cruz, Andrea; Fernandes, Elisabete; Rodrigues, Raquel Oliveira; Catarino, Susana Oliveira; Pinho, Diana[Excerpt] Introduction Miniaturization has played a pivotal role in driving innovation in microfluidic devices, particularly in their application across advanced technologies, such as Lab-on-chip platforms, Point-of-care systems, Organ-, Body- and Disease-on-a-chip technology. The personalized nature inherent in these systems, coupled with physiologically relevant readouts, opens novel avenues for individualize...
Uma rede de soutos demonstração
Carneiro, Rui; Batista, J.; Pereira, Abel; Droga, Rui; Espírio-Santo, J.; Pires, A.; Carmo, M.; Seco, F.; Freitas, Mariano; Ramos, Carlos; Raimundo, F.A estrutura organizativa da rede é constituída por 8 soutos demonstração (SD) e está assim definida: SD Salgueiros- Vinhais (SD S_V); Gestão- Arborea | Supervisão- IPB SD Parada – Bragança (SD P_B); Gestão- Sortegel | Supervisão- IPB SD Lagoa – Vila Pouca de Aguiar (SD L_VPA); Gestão- AguiarFloresta | Supervisão- UTAD SD Carrazedo Montenegro – Valpaços (SD CM_V); Gestão- Agrifuturo | Supervisão- UTAD SD Refoios...
Recent advances on the thermal properties and applications of nanofluids: from ...
Souza, Reinaldo Rodrigues; Gonçalves, Inês M.; Rodrigues, Raquel Oliveira; Minas, Graça; Miranda, J. M.; Moreira, António L. N.The nanofluids (NFs) are known as a colloidal suspension where nanoparticles (NPs) are dispersed in conventional base fluids (BFs). This suspension has been frequently used to augment the heat transfer (HT) capacity of a fluid by studying their thermophysical properties. This review outlines the most recent advances on the NFs thermal properties and on their applications that are being used in different fields ...
CMEMS-UMinho research centre: building advanced strategies on miniaturized biom...
Cardoso, Vanessa Fernandes; Catarino, Susana Oliveira; Minas, Graça; Pinto, Vânia Cristina Gonçalves; Rodrigues, Raquel OliveiraMiniaturized platforms have been under intensive development in many technological fields including biomedicine, pharmacology, biosecurity, food safety, environmental monitoring, among others. They are ideally miniature versions of their macroscale counterparts and thus usually integrate all components units of a complete laboratory assay. The attractiveness of miniaturization, especially in the biomedical fiel...