9 documents found, page 1 of 1
A Vida Secreta da Galinhola: Investigar Esta Esquiva Espécie Cinegética em São ...
O'Hehir, Sophie; Pavão, Diogo C.; Rodrigues, Tiago M.; Leitão, Manuel; Silva, Luís F.; Gonçalves, DavidA galinhola (Scolopax rusticola) é uma espécie cinegética importante nos Açores e em toda a Europa. Contudo, em São Miguel, infelizmente, é uma ave raramente avistada. A sua caça na ilha não é permitida há décadas, uma vez que o seu efetivo é muito reduzido. A população de galinhola nos Açores é residente, o que significa que não migra sazonalmente, para se reproduzir ou invernar. Com todo o seu ciclo de vida p...
Programa de investigação em espécies cinegéticas nos Açores
Pavão, Diogo C.; Rodrigues, Tiago M.; Leitão, M.; Gonçalves, D.A 19 de maio de 2023 foi assinado um Acordo de Cooperação entre a, então, Secretaria Regional da Agricultura e do Desenvolvimento Rural, atualmente Secretaria Regional da Agricultura e Alimentação (SRAA) e a Associação BIOPOLIS (Universidade do Porto). O acordo tem a duração de cinco anos e visa o desenvolvimento de um “Programa de investigação em espécies cinegéticas nos Açores”.
A small TAT-TrkB peptide prevents BDNF receptor cleavage and restores synaptic ...
Fonseca-Gomes, João; Costa-Coelho, Tiago; Ferreira-Manso, Mafalda; Inteiro-Oliveira, Sara; Vaz, Sandra H.; Alemãn-Serrano, NunoIn Alzheimer's disease (AD), amyloid β (Aβ)-triggered cleavage of TrkB-FL impairs brain-derived neurotrophic factor (BDNF) signaling, thereby compromising neuronal survival, differentiation, and synaptic transmission and plasticity. Using cerebrospinal fluid and postmortem human brain samples, we show that TrkB-FL cleavage occurs from the early stages of the disease and increases as a function of pathology seve...
Challenges of BDNF-based therapies : from common to rare diseases
Miranda-Lourenço, Catarina; Ribeiro Rodrigues, Leonor; Fonseca-Gomes, João; Tanqueiro, Sara; Belo, Rita F.; Ferreira, Catarina B.; Rei, NádiaNeurotrophins are a well-known family of neurotrophic factors that play an important role both in the central and peripheral nervous systems, where they modulate neuronal survival, development, function and plasticity. Brain-derived neurotrophic factor (BDNF) possesses diverse biological functions which are mediated by the activation of two main classes of receptors, the tropomyosin-related kinase (Trk) B and t...
Brain-sparing sympathofacilitators mitigate obesity without adverse cardiovascu...
Mahú, Inês; Barateiro, Andreia; Rial-Pensado, Eva; Martinéz-Sánchez, Noelia; Vaz, Sandra H.; Cal, Pedro M.S.D.; Jenkins, Benjamin; Rodrigues, Tiago M.Anti-obesity drugs in the amphetamine (AMPH) class act in the brain to reduce appetite and increase locomotion. They are also characterized by adverse cardiovascular effects with origin that, despite absence of any in vivo evidence, is attributed to a direct sympathomimetic action in the heart. Here, we show that the cardiac side effects of AMPH originate from the brain and can be circumvented by PEGylation (PE...
Impairment of adenosinergic system in Rett syndrome: novel therapeutic target t...
Miranda-Lourenço, Catarina; Duarte, Sofia T.; Palminha, Cátia; Gaspar, Cláudia; Rodrigues, Tiago M.; Magalhães-Cardoso, Teresa; Rei, NádiaRett syndrome (RTT; OMIM#312750) is mainly caused by mutations in the X-linked MECP2 gene (methyl-CpG-binding protein 2 gene; OMIM*300005), which leads to impairments in the brain-derived neurotrophic factor (BDNF) signalling. The boost of BDNF mediated effects would be a significant breakthrough but it has been hampered by the difficulty to administer BDNF to the central nervous system. Adenosine, an endogenou...
Macular OCT-angiography parameters to predict the clinical stage of nonprolifer...
Rodrigues, Tiago M.; Marques, João P.; Soares, Mário; Simão, Sílvia; Melo, Pedro; Martins, Amélia; Figueira, João; Murta, Joaquim N.; Silva, RufinoBackground: To test whether a single or a composite set of macular vascular density parameters, evaluated with optical coherence tomography angiography (OCTA), are able to predict nonproliferative diabetic retinopathy (NPDR) staging according to the gold-standard ETDRS-grading scheme. Methods: Prospectively defined, cross-sectional study in which macular structural and vascular parameters of diabetic eyes with ...
Peripapillary neurovascular coupling in the early stages of diabetic retinopathy
Rodrigues, Tiago M.; Marques, João P.; Soares, Mário; Dolan, Michael-John; Melo, Pedro; Simão, Sílvia; Teles, João; Figueira, João; Murta, Joaquim N.Purpose: To study radial peripapillary capillary (RPC) density in the early stages of diabetic retinopathy (DR), using optical coherence tomography angiography. Methods: A cross-sectional evaluation of RPCs was performed using optical coherence tomography angiography (Avanti RTVue-XR 100, Optovue Inc, Fremont, CA). Annular RPC density was the primary outcome. Global density and retinal nerve fiber layer thickne...
Challenges and promises in the development of neurotrophic factor-based therapi...
Rodrigues, Tiago M.; Jerónimo-Santos, André; Outeiro, Tiago; Sebastião, Ana M; Diógenes, Maria JoséParkinson's disease (PD) is a chronic movement disorder typically coupled to progressive degeneration of dopaminergic neurons in the substantia nigra (SN). The treatments currently available are satisfactory for symptomatic management, but the efficacy tends to decrease as neuronal loss progresses. Neurotrophic factors (NTFs) are endogenous proteins known to promote neuronal survival, even in degenerating state...